Buerger's disease (thromboangiitis obliterans) is a rare disease of the arteries and veins in the arms and legs. In Buerger's disease, your blood vessels become inflamed, swell and can become blocked with blood clots (thrombi).

This eventually damages or destroys skin tissues and may lead to infection and gangrene. Buerger's disease usually first shows in your hands and feet and may eventually affect larger areas of your arms and legs.

Virtually everyone diagnosed with Buerger's disease smokes cigarettes or uses other forms of tobacco, such as chewing tobacco. Quitting all forms of tobacco is the only way to stop Buerger's disease. For those who don't quit, amputation of all or part of a limb is sometimes necessary.

Buerger's disease care at Mayo Clinic

Jan. 28, 2016
  1. Buerger's disease. National Organization for Rare Disorders. http://rarediseases.org/rare-diseases/buergers-disease/. Accessed Nov. 19, 2015.
  2. Olin, JW. Thromboangiitis obliterans (Buerger's disease). http://www.uptodate.com/home. Accessed Nov. 19, 2015.
  3. Cronenwett JL, et al. Thromboangiitis obliterans (Buerger's disease). In: Rutherford's Vascular Surgery. 8th ed. Philadelphia, Pa.: Saunders Elsevier, Inc.; 2014. http://www.clinicalkey.com. Accessed Nov. 19, 2015.
  4. Del Conde I, et al. Thromboangiitis obliterans (Buerger's disease). Techniques in Vascular and Interventional Radiology. 2014;17:234.
  5. Igari K, et al. The epidemiologic and clinical findings of patients with Buerger disease. Annals of Vascular Surgery. In press. Accessed Nov. 19, 2015.
  6. Riggs EA. AllScripts EPSi. Mayo Clinic, Rochester, Minn. Oct. 20, 2015.