Symptoms and causes

Symptoms

Lewy body dementia signs and symptoms may include:

  • Visual hallucinations. Hallucinations may be one of the first symptoms, and they often recur. They may include seeing shapes, animals or people that aren't there. Sound (auditory), smell (olfactory) or touch (tactile) hallucinations are possible.
  • Movement disorders. Signs of Parkinson's disease (parkinsonian symptoms), such as slowed movement, rigid muscles, tremor or a shuffling walk may occur.
  • Poor regulation of body functions (autonomic nervous system). Blood pressure, pulse, sweating and the digestive process are regulated by a part of the nervous system that is often affected by Lewy body dementia. This can result in dizziness, falls and bowel issues such as constipation.
  • Cognitive problems. You may experience thinking (cognitive) problems similar to those of Alzheimer's disease, such as confusion, poor attention, visual-spatial problems and memory loss.
  • Sleep difficulties. You may have rapid eye movement (REM) sleep behavior disorder, which can cause you to physically act out your dreams while you're asleep.
  • Fluctuating attention. Episodes of drowsiness, long periods of staring into space, long naps during the day or disorganized speech are possible.
  • Depression. You may experience depression sometime during the course of your illness.
  • Apathy. You may have loss of motivation.

Causes

Lewy body dementia is characterized by the abnormal buildup of proteins into masses known as Lewy bodies. This protein is also associated with Parkinson's disease. People who have Lewy bodies in their brains also have the plaques and tangles associated with Alzheimer's disease.

Risk factors

A few factors seem to increase the risk of developing Lewy body dementia, including:

  • Being older than 60
  • Being male
  • Having a family member with Lewy body dementia or Parkinson's disease

Research has indicated that depression is also associated with Lewy body dementia.

Complications

Lewy body dementia is progressive. Signs and symptoms worsen, causing:

  • Severe dementia
  • Aggressive behavior
  • Depression
  • Increased risk of falling and injury
  • Worsening of parkinsonian symptoms, such as tremors
  • Death, on average about eight years after symptoms start
April 19, 2016
References
  1. NINDS Dementia with Lewy bodies information page. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/dementiawithlewybodies/dementiawithlewybodies.htm. Accessed Feb. 16, 2016.
  2. Hake AM, et al. Clinical features and diagnosis of dementia with Lewy bodies. http://www.uptodate.com/home. Accessed Feb. 16, 2016.
  3. Hake AM, et al. Epidemiology, pathology, and pathogenesis of dementia with Lewy bodies. http://www.uptodate.com/home. Accessed Feb. 16, 2016.
  4. Diagnosis. Lewy Body Dementia Association. http://www.lbda.org/content/diagnosis. Accessed Feb. 16, 2016.
  5. Hake AM, et al. Prognosis and treatment of dementia with Lewy bodies. http://www.uptodate.com/home. Accessed Feb. 16, 2016.
  6. Symptoms. Lewy Body Dementia Association. http://www.lbda.org/content/symptoms. Accessed Feb. 16, 2016.
  7. Neurological diagnostic tests and procedures. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/misc/diagnostic_tests.htm. Accessed Feb. 16, 2016.
  8. Shadlen MF, et al. Evaluation of cognitive impairment and dementia. http://www.uptodate.com/home. Accessed Feb. 16, 2016.
  9. Dementia: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/dementias/detail_dementia.htm. Accessed Feb. 16, 2016.
  10. Communication and Alzheimer's. Alzheimer's Association. http://www.alz.org/care/dementia-communication-tips.asp. Accessed Feb. 16, 2016.
  11. Creating a daily plan. Alzheimer's Association. http://www.alz.org/care/dementia-creating-a-plan.asp. Accessed Feb. 16, 2016.
  12. Press D. Treatment of dementia. http://www.uptodate.com/home. Accessed Feb. 16, 2016.
  13. Sleep issues and sundowning. Alzheimer's Association. http://www.alz.org/care/alzheimers-dementia-sleep-issues-sundowning.asp. Accessed Feb. 16, 2016.
  14. Buettner LL, et al. Animal-assisted therapy for clients with dementia. Journal of Gerontological Nursing. 2011;37:10.
  15. Being a healthy caregiver. Alzheimer's Association. http://www.alz.org/care/alzheimers-dementia-healthy-caregiver.asp. Accessed Feb. 16, 2016.
  16. Respite care. Alzheimer's Association. http://www.alz.org/care/alzheimers-dementia-caregiver-respite.asp. Accessed Feb. 16, 2016.
  17. Caregiver stress. Alzheimer's Association. http://www.alz.org/care/alzheimers-dementia-caregiver-stress-burnout.asp. Accessed Feb. 16, 2016.
  18. Dementia with Lewy bodies. Alzheimer's Association. http://www.alz.org/dementia/dementia-with-lewy-bodies-symptoms.asp. Accessed Feb. 16, 2016.
  19. Home safety and Alzheimer's. Alzheimer's Association. https://www.alz.org/care/alzheimers-dementia-home-safety.asp. Accessed Feb. 16, 2016.
  20. Stay mentally active. Alzheimer's Association. https://www.alz.org/care/alzheimers-dementia-home-safety.asp. Accessed Feb. 18, 2016.
  21. Press D, et al. Management of neuropsychiatric symptoms of dementia. http://www.uptodate.com/home. Accessed Feb. 18, 2016.
  22. Therapeutic activities. Fisher Center for Alzheimer's Research Foundation. https://www.alzinfo.org/articles/therapeutic-activities/. Accessed Feb. 18, 2016.
  23. Boot BP, et al. Risk factors for dementia with Lewy bodies. Neurology. 2013; 81: 833.
  24. Graff-Radford J (expert opinion). Mayo Clinic, Rochester, Minn. Feb. 22, 2016.