The first sign of Merkel cell carcinoma is usually a fast-growing, painless nodule (tumor) on your skin. The nodule may be skin colored or may appear in shades of red, blue or purple. Most Merkel cell carcinomas appear on the face, head or neck, but they can develop anywhere on your body, even on areas not exposed to sunlight.
When to see a doctor
If you notice a mole, freckle or bump that is changing in size, shape or color, growing rapidly, or bleeding easily after minor trauma, such as washing your skin or shaving, make an appointment with your doctor.
It's not clear what causes Merkel cell carcinoma. Merkel cell carcinoma begins in the Merkel cells. Merkel cells are found at the base of the outermost layer of your skin (epidermis). Merkel cells are connected to the nerve endings in the skin that are responsible for the sense of touch.
Researchers recently discovered that a common virus plays a role in causing most cases of Merkel cell carcinoma. The virus (Merkel cell polyomavirus) lives on the skin and doesn't cause any signs and symptoms. Just how this virus causes Merkel cell carcinoma has yet to be determined. Given that the virus is very common and Merkel cell carcinoma is very rare, it's likely that other risk factors play a role in the development of this cancer.
Factors that may increase your risk of Merkel cell carcinoma include:
- Excessive exposure to natural or artificial sunlight. Being exposed to ultraviolet light, such as the light that comes from the sun or from tanning beds, increases your risk of Merkel cell carcinoma. The majority of Merkel cell carcinomas appear on skin surfaces frequently exposed to sun.
- A weakened immune system. People with weakened immune systems — including those with HIV infection, those taking drugs that suppress the immune response or those with chronic leukemias — are more likely to develop Merkel cell carcinoma.
- History of other skin cancers. Merkel cell carcinoma is associated with the development of other skin cancers, such as basal cell or squamous cell carcinoma.
- Older age. Your risk of Merkel cell carcinoma increases as you age. This cancer is most common in people older than age 50, though it can occur at any age.
- Light skin color. Merkel cell carcinoma usually arises in people who have light-colored skin. Whites are much more likely to be affected by this skin cancer than are blacks.
Cancer that spreads to other parts of the body
Even with treatment, Merkel cell carcinoma commonly spreads (metastasizes) beyond the skin. Merkel cell carcinoma tends to travel first to nearby lymph nodes. Later it may spread to your brain, bones, liver or lungs, where it can interfere with the functioning of these organs. Cancer that has metastasized is more difficult to treat and can be fatal.
Dec. 09, 2015
- Niederhuber JE, et al., eds. Nonmelanoma skin cancers. In: Abeloff's Clinical Oncology. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2014. http://www.clinicalkey.com. Accessed Aug. 5, 2015.
- Merkel cell carcinoma. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Aug. 5, 2015.
- Merkel cell carcinoma treatment (PDQ). National Cancer Institute. http://www.cancer.gov/types/skin/patient/merkel-cell-treatment-pdq#section/all. Accessed Sept. 3, 2015.
- Prevent skin cancer. American Academy of Dermatology. http://www.aad.org/spot-skin-cancer/learn-about-skin-cancer/prevent-skin-cancer. Accessed Sept. 3, 2015.
- Tai, P. Pathogenesis, clinical features, and diagnosis of Merkel cell (neuroendocrine) carcinoma. http://www.uptodate.com/home. Accessed Sept. 5, 2015.
- Church CD, et al. How does the Merkel polyomavirus lead to a lethal cancer? Many answers, many questions and a new mouse model. Journal of Investigative Dermatology. 2015;135:1222.