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By Mayo Clinic staffSymptoms of dermatographia usually go away on their own, and treatment for dermatographia generally isn't necessary. However, if the condition is severe or bothersome, your doctor may recommend antihistamine medications. These drugs block histamine, an inflammatory chemical released by your immune system during an allergic reaction. A low dose of antihistamine usually provides relief at the time of the reaction. You might need to take medication on a regular basis if your symptoms are severe.