DefinitionBy Mayo Clinic staff
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Acanthosis nigricans (ak-an-THOE-sis NIE-grih-kuns) is a skin condition characterized by areas of dark, velvety discoloration in body folds and creases. The affected skin can become thickened and may smell bad. Most often, acanthosis nigricans affects your armpits, groin and neck.
These skin changes typically occur in people who are obese or have diabetes. Children who develop the condition are at higher risk of developing type 2 diabetes. More rarely, acanthosis nigricans can be a warning sign of a cancerous tumor in an internal organ, such as the stomach or liver.
Acanthosis nigricans is most common in Native Americans, blacks and Hispanics. There's no specific treatment for acanthosis nigricans. Treatment of underlying conditions may restore some of the normal color and texture to affected areas of skin.
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