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Treatments and drugs
By Mayo Clinic staffThere's no specific treatment for acanthosis nigricans. Treating any underlying conditions may cause the skin changes to fade, however. If you're overweight, losing excess pounds can help. Sometimes dietary changes are helpful, too.
Lightening affected areas
If you're concerned about the appearance of your skin, your doctor may prescribe a cream or lotion to help lighten the affected areas. Some of these lotions contain modified vitamin A products, such as tretinoin (Retin-A, others), or other medications. Sometimes oral medications, such as isotretinoin (Accutane, others), are helpful. Fish oil supplements also may be recommended. Dermabrasion or laser therapy may help reduce the thickness of certain affected areas.
