Acute lymphocytic leukemia

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Tests and diagnosis

By Mayo Clinic staff

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Illustration showing a needle suctioning out liquid bone marrow from the hipbone 
Bone marrow biopsy

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Tests and procedures used to diagnose acute lymphocytic leukemia include:

  • Blood tests. A blood test may reveal too many white blood cells, not enough red blood cells and not enough platelets. A blood test may also show the presence of blast cells - immature cells normally found in the bone marrow but not circulating in the blood.
  • Bone marrow test. During bone marrow aspiration, a needle is used to remove a sample of bone marrow from the hipbone to look for leukemia cells. The sample is sent to a lab for testing. Doctors in the lab will classify blood cells into specific types based on their size, shape and other features. They also look for certain changes in the cancer cells and determine whether the leukemia cells began from the B lymphocytes or T lymphocytes. This information helps your doctor develop a treatment plan.
  • Imaging tests. Imaging tests such as a chest X-ray and computerized tomography (CT) scan may help determine whether cancer has spread to the brain and spinal cord or other parts of the body.
  • Spinal fluid test. A lumbar puncture test, also called a spinal tap, may be used to collect a sample of spinal fluid. The sample is tested to see whether cancer cells have spread to the spinal fluid.
References
  1. Rabin KR, et al. Clinical manifestations of acute lymphoblastic leukemia. In: Hoffman R, et al. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, Pa.: Churchill Livingstone; 2009. http://www.mdconsult.com/book/player/book.do?method=display&type=aboutPage&decorator=header&eid=4-u1.0-B978-0-443-06715-0..X5001-8--TOP&isbn=978-0-443-06715-0&uniq=210978719. Accessed Aug. 16, 2010.
  2. Hoelzer D, et al. Acute lymphocytic leukemia in adults. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2007:2191.
  3. Pieters R, et al. Biology and treatment of acute lymphoblastic leukemia. Hematology and Oncology Clinics of North America. 2010;24:1.
  4. Acute lymphocytic leukemia. The Leukemia & Lymphoma Society. http://www.leukemia-lymphoma.org/all_page?item_id=7049. Accessed Aug. 16, 2010.
  5. Integrative medicine and complementary and alternative therapies as part of blood cancer care. The Leukemia & Lymphoma Society. http://www.leukemia-lymphoma.org/attachments/National/br_1150734030.pdf. Accessed Aug. 16, 2010.
  6. Faderl S, et al. Adult acute lymphoblastic leukemia. Cancer. 2010;116:1165.
DS00558 Sept. 4, 2010

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