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Tests and diagnosis

By Mayo Clinic staff

Diagnosing age spots may include:

  • Visual inspection. Your doctor can usually diagnose age spots by visually inspecting your skin.
  • Skin biopsy. If there's any doubt, your doctor may do other tests, such as a skin biopsy. During a skin biopsy, your doctor takes a small sample of your skin (biopsy) for microscopic analysis. A skin biopsy is usually done in a doctor's office, using a local anesthetic.

Other conditions
Other conditions that can look similar to age spots and that your doctor may need to rule out include the following:

  • Moles. Although they often appear as small, dark brown spots, moles (nevi) vary in color and size. They can be raised or flat and can develop almost anywhere on your body.
  • Seborrheic keratoses. These tan, brown or black growths have a wart-like or waxy, pasted-on appearance and range in size from very small to more than 1 inch (2.5 centimeters) across.
  • Lentigo maligna. A type of skin cancer known as lentigo maligna melanoma can develop in areas of long-term sun exposure. Lentigo maligna starts as tan, brown or black lesions that slowly darken and enlarge. They tend to have an irregular border and uneven coloring, and they may be slightly raised.
References
  1. Goldstein BG, et al. Overview of benign lesions of the skin. http://www.uptodate.com/home/index.html. Accessed Dec. 13, 2010.
  2. Schaffer JV, et al. Benign pigmented skin lesions other than melanocytic nevi (moles). http://www.uptodate.com/home/index.html. Accessed Dec. 13, 2010.
  3. Ortonne JP et al. Treatment of solar lentigines. Journal of the American Academy of Dermatology. 2006;54:S262.
  4. Melanoma (malignant melanoma). The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/sec10/ch128/ch128e.html. Accessed Dec. 14, 2010.
  5. Kang HY, et al. The role of topical retinoids in the treatment of pigmentary disorders: An evidence-based review. American Journal of Clinical Dermatology. 2009;10:251.
  6. Draelos ZD. Skin lightening preparations and the hydroquinone controversy. Dermatologic Therapy. 2007;20:308.
  7. Facts about sunscreens. American Academy of Dermatology. http://www.aad.org/media/background/factsheets/fact_sunscreen.htm. Accessed Dec. 14, 2010.
  8. Sun-protective clothing: Wear it well. Federal Trade Commission. http://www.ftc.gov/bcp/edu/pubs/consumer/alerts/alt094.shtm. Accessed Dec. 14, 2010.
DS00912 Feb. 24, 2011

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