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  • With Mayo Clinic medical oncologist

    Timothy Moynihan, M.D.

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Mayo Clinic Health Manager

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Question

High-dose vitamin C: Can it kill cancer cells?

I have been reading about vitamin C as an alternative cancer treatment. What can you tell me about it?

Answer

from Timothy Moynihan, M.D.

The use of vitamin C in alternative cancer treatment isn't new. Proponents claim that large doses of vitamin C are toxic to cancer cells. However, there is no reliable evidence to support this theory.

Studies in the 1970s first suggested that large doses of supplemental vitamin C might be of some benefit in the treatment of cancer. But these studies were later found to have serious flaws. Subsequent well-designed, randomized, controlled trials of vitamin C and cancer found no such treatment benefit.

More recently, intravenous (IV) vitamin C has been touted to have different effects than does vitamin C taken orally. This has sparked renewed interest in the use of IV vitamin C as a cancer therapy. However, there is still no evidence that vitamin C has any effect on cancer. Until clinical trials are completed, it's premature to determine what role, if any, IV vitamin C may play in the treatment of cancer.

Next question
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References
  1. Verrax J, et al. The controversial place of vitamin C in cancer treatment. Biochemical Pharmacology. 2008;76:1644.
  2. Hoffer LJ, et al. Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Annals of Oncology. 2008;19:1969.
  3. Heaney ML, et al. Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Research. 2008;68:8031.
  4. Coulter ID, et al. Antioxidants vitamin C and vitamin E for the prevention and treatment of cancer. Journal of General Internal Medicine. 2006;21:735.
  5. Borst P. Mega-dose vitamin C as therapy for human cancer? Proceedings of the National Academy of Sciences. 2008;105:E95.

AN01572

April 1, 2009

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