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Causes
By Mayo Clinic staffDoctors don't know what causes anal cancer. What's known is that something occurs to create a genetic mutation within a cell that can lead to anal cancer.
In general, cancer begins with a genetic mutation that turns normal, healthy cells into abnormal cells. Healthy cells grow and multiply at a set rate, eventually dying at a set time. Abnormal cells grow and multiply out of control, and they don't die. The accumulating abnormal cells form a mass (tumor). Cancer cells invade nearby tissues and can separate from an initial tumor to spread elsewhere in the body (metastasize).
- Complementary and alternative methods for cancer management. American Cancer Society. http://www.cancer.org/docroot/ETO/content/ETO_5_1_Introduction.asp. Accessed Nov. 7, 2008.
- Anal carcinoma. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/anal.pdf. Accessed Nov. 3, 2008.
- Anal cancer treatment (PDQ) patient version. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/anal/patient/allpages/print. Accessed Nov. 3, 2008.
- SEER stat fact sheets. Surveillance Epidemiology and End Results. http://seer.cancer.gov/statfacts/html/anus.html. Accessed Nov. 3, 2008.
- Malik U, et al. Cancer of the anal canal. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2008:1557.
- Can anal cancer be prevented? American Cancer Society. http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_Can_Anal_Cancer_be_prevented_47.asp?sitearea=. Accessed Nov. 7, 2008.
- Questions to ask the doctor. Cancer.Net. http://www.cancer.net/patient/Cancer+Types/Anal+Cancer. Accessed Nov. 7, 2008.
