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Causes

By Mayo Clinic staff

Living With Cancer

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Anal cancer forms when a genetic mutation turns normal, healthy cells into abnormal cells. Healthy cells grow and multiply at a set rate, eventually dying at a set time. Abnormal cells grow and multiply out of control, and they don't die. The accumulating abnormal cells form a mass (tumor). Cancer cells invade nearby tissues and can separate from an initial tumor to spread elsewhere in the body (metastasize).

Anal cancer is closely related to a sexually transmitted infection called human papillomavirus (HPV). Evidence of HPV is detected in the majority of anal cancers. HPV is thought to be the most common cause of anal cancers.

Risk factors Symptoms
References
  1. Deng GE, et al. Evidence-based clinical practice guidelines for integrative oncology: Complementary therapies and botanicals. Journal of the Society for Integrative Oncology. 2009;7:85.
  2. Anal carcinoma. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/PDF/anal.pdf. Accessed Oct. 19, 2010.
  3. Anal cancer treatment (PDQ). National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/anal/patient. Accessed Oct. 19, 2010.
  4. Malik U, et al. Cancer of the anal canal. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2008:1557.
  5. Gardasil (prescribing information). Whitehouse Station, N.J.: Merck & Co. Inc.; 2009. http://www.merck.com/product/usa/pi_circulars/g/gardasil/gardasil_pi.pdf. Accessed Oct. 20, 2010.
  6. Cervarix (prescribing information). Research Triangle Park, N.C.: GlaxoSmithKline; 2009. http://us.gsk.com/products/assets/us_cervarix.pdf. Accessed Oct. 20, 2010.
  7. Joseph DA, et al. Understanding the burden of human papillomavirus-associated anal cancers in the U.S. Cancer. 2008;113(suppl):2892.
  8. Moynihan TJ (expert opinion). Mayo Clinic, Rochester, Minn. Oct. 28, 2010.
DS00852 Dec. 23, 2010

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