Antacids: A cause of drug interactions?

Is it true that antacids inhibit absorption of some medications?

- Ann / Pennsylvania

Mayo Clinic gastroenterologist Michael Picco, M.D., and colleagues answer select questions from readers.

Answer

Antacids can interact with many medications. A drug interaction occurs when one drug interferes with another drug. This can alter the way one or both drugs work or cause unexpected side effects.

Medications known to interact with antacids include:

Antibiotics, such as tetracyclines or quinolones (Levaquin, Cipro)
Antifungals, such as itraconazole (Sporanox)
Digoxin (Lanoxin), a medication used to treat congestive heart failure
Iron supplements

To reduce or prevent drug interactions with antacids, it is generally recommended that you take antacids at least one hour before or two hours after other medications. Tell your doctor if you take antacids on a regular basis, since they may interact with other medications you are taking.