Antibiotic-associated diarrhea


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Definition

By Mayo Clinic staff

Antibiotic-associated diarrhea describes frequent, watery bowel movements (diarrhea) that occur in response to medications used to treat bacterial infections (antibiotics).

Most often, antibiotic-associated diarrhea is mild and clears up shortly after you stop taking the antibiotic. But in some cases, antibiotic-associated diarrhea leads to colitis, an inflammation of your colon, or a more serious form of colitis called pseudomembranous colitis. Both can cause abdominal pain, fever and bloody diarrhea.

Mild antibiotic-associated diarrhea may not require treatment. More serious antibiotic-associated diarrhea may require stopping or switching antibiotic medications.

References
  1. Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed March 30, 2013.
  2. Rakel RE. Textbook of Family Medicine. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/das/book/body/191205553-4/0/1481/0.html#. Accessed March 30, 2013.
  3. Diarrhea. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/diarrhea/#treated. Accessed March 27, 2013.
  4. LaMont JT. Clostridium difficile in adults: Clinical manifestations and diagnosis. http://www.uptodate.com/home/html. Accessed March 25, 2013.
  5. Ray CG, et al., eds. Sherris Medical Microbiology. 5th ed. New York, N.Y.: The McGraw-Hill Companies; 2010. http://www.accessmedicine.com/content.aspx?aID=6936101. Accessed April 2, 2013.
  6. LaMont JT. Clostridium difficile in adults: Epidemiology, microbiology, and pathophysiology. http://www.uptodate.com/home. Accessed March 25, 2013.
  7. Rebmann T, et al. Preventing Clostridium difficile infections: An executive summary of the Association for Professionals in Infection Control and Epidemiology's elimination guide. American Journal of Infection Control. 2011;39:239.
  8. Surawicz CM, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. The American Journal of Gastroenterology. In press. Accessed March 25, 2013.
  9. Wanke CA. Approach to the adult with acute diarrhea in developed countries. http://www.uptodate.com/home. Accessed April 2, 2013.
  10. Hempel S, et al. Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea. Journal of the American Medical Association. 2012;307:1959.
  11. Rohren CH (expert opinion). Mayo Clinic, Rochester, Minn. April 8, 2013.
DS00454 June 11, 2013

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