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Risk factors

By Mayo Clinic staff

Heart-Healthy Living

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Aortic valve stenosis isn't considered preventable. Some risk factors include:

  • A deformed aortic valve. Some people are born with an already narrowed aortic valve or develop aortic valve stenosis later in life because they were born with a bicuspid aortic valve — one with two flaps (leaflets) instead of three. A bicuspid aortic valve is a major risk factor for aortic valve stenosis. A bicuspid aortic valve can run in families, so knowing your family history is important. If you have a first-degree relative — a parent, sibling or child — with a bicuspid aortic valve, it is reasonable to check to see if you have this abnormality.
  • Age. Aortic valve stenosis may be related to increasing age and the buildup of calcium deposits on heart valves.
  • Previous rheumatic fever. Rheumatic fever can cause the flaps (leaflets) of your aortic valve to stiffen and fuse, eventually resulting in aortic valve stenosis.

Risk factors for aortic valve stenosis and atherosclerotic heart disease — such as high blood pressure, high cholesterol, type 2 diabetes and smoking — may indicate a link between the two.

References
  1. Aortic valve stenosis (AVS). American Heart Association. http://www.heart.org/HEARTORG/Conditions/CongenitalHeartDefects/AboutCongenitalHeartDefects/Aortic-Valve-Stenosis-AVS_UCM_307020_Article.jsp. Accessed June 10, 2011.
  2. Rakel RE, et al. Valvular heart disease. In: Rakel RE. Textbook of Family Medicine. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2011. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-1160-8..10027-2--s0310&isbn=978-1-4377-1160-8&uniqId=258746827-3. Accessed June 12, 2011.
  3. Grimard BH, et al. Aortic stenosis: Diagnosis and treatment. American Family Physician. 2008;78:717.
  4. Aortic valve stenosis (AS) and aortic insufficiency (AI). American Heart Association. http://www.heart.org/idc/groups/heart-public/@wcm/@hcm/documents/downloadable/ucm_307649.pdf. Accessed June 12, 2011.
  5. Aortic stenosis. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec07/ch076/ch076c.html. Accessed June 12, 2011.
  6. Otto CM, et al. Valvular Heart Disease. In: Bonow RO, et al. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2011. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-0398-6..00066-4&isbn=978-1-4377-0398-6&uniqId=258746827-3#4-u1.0-B978-1-4377-0398-6..00066-4--s0060. Accessed June 12, 2011.
  7. How the healthy heart works. American Heart Association. http://www.heart.org/HEARTORG/Conditions/CongenitalHeartDefects/AboutCongenitalHeartDefects/How-the-Healthy-Heart-Works_UCM_307016_Article.jsp. Accessed June 12, 2011.
  8. Zigelman CZ, et al. Aortic Valve Stenosis. Anesthesiology Clinics. 2009;27:519.
  9. Carabello BA, et al. Aortic stenosis. In: Crawford MH. Current Diagnosis & Treatment: Cardiology. 3rd ed. New York, N.Y.: The McGraw-Hill Companies; 2009. http://www.accessmedicine.com/content.aspx?aID=3646810&searchStr=aortic+valve+stenosis#3646810. Accessed June 12, 2011.
  10. Coeytaux RR, et al. Percutaneous heart valve replacement for aortic stenosis: State of the evidence. Annals of Internal Medicine. 2010;153:314.
  11. Smith CR, et al. Transcatheter versus surgical aortic-valve replacement in high-risk patients. New England Journal of Medicine. 2011;364:2187.
  12. Lockhart PB, et al. Poor oral hygiene as a risk factor for infective endocarditis-related bacteremia. Journal of the American Dental Association. 2009;140:1238.
DS00418 July 13, 2012

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