Aspirin allergy: What are the symptoms?

I've been told that I may have an aspirin allergy. What are the symptoms?

- Joseph / California

Mayo Clinic asthma and allergy specialist James Li, M.D., and colleagues answer select questions from readers.

Answer

Aspirin sensitivity is common, especially in people with asthma or sinus problems. But a true aspirin allergy — in which your immune system overreacts to the drug — is rare. Signs and symptoms of aspirin allergy or sensitivity range from mild to serious and may include:

Hives
Itchy skin
Itchy, watery eyes
Swelling of the lips, tongue or face
Breathing difficulty or wheezing

These signs and symptoms usually occur within a few hours of taking the medication.

If you've had a reaction to aspirin, you should avoid all forms of aspirin, as well as other nonsteroidal anti-inflammatory drugs, such as ibuprofen and naproxen, which are chemically similar to aspirin. These drugs are found in many over-the-counter (nonprescription) medications. So check the label carefully.

If you think you might have an aspirin allergy, consult your doctor or allergist for advice. In rare cases, life-threatening reactions such as anaphylaxis can occur.