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  • With Mayo Clinic obstetrician and medical editor-in-chief

    Roger W. Harms, M.D.

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Question

Aspirin during pregnancy: Is it safe?

Is it safe to take aspirin during pregnancy?

Answer

from Roger W. Harms, M.D.

Generally, aspirin and ibuprofen (Advil, Motrin IB, others) aren't recommended as pain relievers during pregnancy.

Aspirin interferes with your blood's clotting action. As a result, taking aspirin during pregnancy — especially after 32 weeks — can contribute to maternal and fetal bleeding. Aspirin and ibuprofen can also cause the premature closure of a vessel in a baby's heart, which can lead to high blood pressure in the baby's lungs (pulmonary hypertension), and prolong labor.

However, low-dose aspirin therapy is sometimes prescribed during pregnancy to help treat medical conditions. If you need to take aspirin during your third trimester of pregnancy, your health care provider will likely closely monitor you and your baby.

If you need to take a pain reliever during pregnancy, ask your health care provider about the options. He or she might approve occasional use of acetaminophen (Tylenol, others).

Next question
Headaches during pregnancy: What's the best treatment?
References
  1. Tulandi T, et al. Management of couples with recurrent pregnancy loss. http://www.uptodate.com/index. Accessed Aug. 17, 2012.
  2. Risser A, et al. NSAID prescribing precautions. American Family Physician. 2009;80:1371.
  3. James AH, et al. Aspirin and reproductive outcomes. Obstetrical and Gynecological Survey. 2008;63:49.
  4. Briggs GG, et al. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. 9th ed. Philadelphia, Pa.: Wolters Kluwer Health Lippincott Williams & Wilkins; 2011.
  5. Lee MJ, et al. Headache in pregnancy. http://www.uptodate.com/index. Accessed Aug. 17, 2012.
  6. Acetaminophen and pregnancy. Organization of Teratology Information Specialists. http://www.otispregnancy.org/files/acetaminophen.pdf. Accessed Aug. 17, 2012.
  7. Ibuprofen and pregnancy. Organization of Teratology Information Specialists. http://www.otispregnancy.org/files/ibuprofen.pdf. Accessed Aug. 17, 2012.
  8. Gibbs RS, et al. Danforth's Obstetrics and Gynecology. 10th ed. Philadelphia, Pa.: Wolters Kluwer Health Lippincott Williams & Wilkins; 2008. http://www.danforthsobgyn.com. Accessed Aug. 17, 2012.
AN01897 Nov. 10, 2012

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