• image.alt
  • With Mayo Clinic obstetrician and medical editor-in-chief

    Roger W. Harms, M.D.

    read biography

Free

E-Newsletters

Subscribe to receive the latest updates on health topics. About our newsletters

  • Housecall
  • Alzheimer's caregiving
  • Living with cancer

Question

Aspirin during pregnancy: Is it safe?

Is it safe to take aspirin during pregnancy?

Answer

from Roger W. Harms, M.D.

Low-dose aspirin therapy is sometimes prescribed during pregnancy to help prevent recurrent miscarriage or to treat other conditions. Generally, however, aspirin and other nonsteroidal anti-inflammatory drugs — including ibuprofen (Advil, Motrin, others) — aren't recommended as pain relievers during pregnancy.

Before birth, a baby receives oxygen through blood from the placenta. At birth, a natural drop in prostaglandin levels in some of the baby's blood vessels drives the baby's circulatory system to reroute blood flow to the lungs. Since aspirin blocks the production of prostaglandins, taking aspirin during pregnancy — especially after 32 weeks — could trigger the baby's blood flow to be rerouted in the uterus. This could cause potentially fatal problems for the baby.

If you need to take a pain reliever during pregnancy, ask your health care provider about the options. He or she may approve occasional use of acetaminophen (Tylenol, others).

Next question
Headaches during pregnancy: What's the best treatment?
References
  1. Tulandi T, et al. Management of couples with recurrent pregnancy loss. http://www.uptodate.com/home/index.html. Accessed May 3, 2010.
  2. Risser A, et al. NSAID prescribing precautions. American Family Physician. 2009;80:1371.
  3. James AH, et al. Aspirin and reproductive outcomes. Obstetrical and Gynecological Survey. 2008;63:49.
  4. Briggs GG, et al. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Philadelphia, Pa.: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008.
AN01897 Aug. 14, 2010

© 1998-2012 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

Print Share Reprints

Advertisement


Text Size: smaller largerlarger