• image.alt
  • With Mayo Clinic endocrinologist

    Maria Collazo-Clavell, M.D.

    read biography

Mayo Clinic Health Manager

Get free personalized health guidance for you and your family.

Get Started

Free

E-Newsletter

Subscribe to receive the latest updates on health topics. About our newsletters

  • Housecall
  • Alzheimer's caregiving
  • Living with cancer

Question

Diabetes management: Does aspirin therapy prevent heart problems?

I've heard that aspirin therapy may not help prevent heart problems when you have diabetes and peripheral artery disease. Should I keep taking it?

Answer

from Maria Collazo-Clavell, M.D.

If you have diabetes, you're at higher risk of heart attack and clot-related stroke (cardiovascular events). Perhipheral artery disease — a condition in which your arteries narrow, reducing blood flow to your arms and legs — also increases your risk of cardiovascular events.

Aspirin interferes with your blood's ability to clot. Because you're at increased risk of cardiovascular events if you have diabetes, daily aspirin therapy is typically recommended as part of a diabetes management plan. Research has shown that aspirin therapy is effective at reducing the risk of heart attack and clot-related strokes if you've had a previous cardiovascular event. It also appears to reduce these risks if you're experiencing symptoms of peripheral artery disease — such as leg cramping, numbness or weakness.

What's not clear is whether aspirin lowers the risk of a cardiovascular event if you haven't experienced one before and you aren't experiencing symptoms of peripheral artery disease. More study is needed on the potential benefits of aspirin therapy in these groups of people. Aspirin therapy does have potential side effects, such as bleeding and bleeding stroke (hemorrhagic stroke). If you have diabetes, peripheral artery disease or both, ask your doctor about daily aspirin therapy, including which strength of aspirin would be best.

Next question
Byetta: Can diabetes drug also help me lose weight?
References
  1. Belch J, et al. The prevention of progression of arterial disease and diabetes (POPADAD) trial: Factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease. British Medical Journal. 2008;337:a1840.
  2. Collazo-Clavell ML (expert opinion). Mayo Clinic, Rochester, Minn. Dec.25, 2008.

AN01958

Feb. 5, 2009

© 1998-2009 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Reliable tools for healthier lives," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

Print Share Reprints

Text Size: smaller largerlarger