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Complications

By Mayo Clinic staff

Managing Depression

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Like other types of depression, atypical depression is a serious illness that can cause major problems. Atypical depression can result in emotional, behavioral and health problems that affect every area of your life. Complications associated with atypical depression may include:

  • Excess weight or obesity, which can lead to heart disease and diabetes
  • Alcohol or drug abuse
  • Anxiety and panic disorder or social phobia
  • Family conflicts, relationship difficulties, and work or school problems
  • Social isolation
  • Suicidal feelings or suicide
Preparing for your appointment Risk factors
References
  1. O'Keane V, et al. A review of atypical depression in relation to the course of depression and changes in HPA axis organization. Psychoneuroendocrinology. 2012. In press. Accessed June 19, 2012.
  2. Atypical features specifier. In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed June 19, 2012.
  3. Cizza G, et al. Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: The power study. Plos One. 2012. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028912. Accessed June 19, 2012.
  4. Pae C, et al. Atypical depression: A comprehensive review. CNS Drugs. 2009;2:1023.
  5. Depression. National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/depression/index.shtml. Accessed June 19, 2012.
  6. McPhee SJ, et al. Current Medical Diagnosis & Treatment. 51st ed. New York, N.Y.: The McGraw-Hill Companies; 2012. http://www.accessmedicine.com/content.aspx?aID=13381. Accessed June 20, 2012.
  7. Parker G, et al. Will a new genotyping test help the clinician predict response to antidepressant drugs? Australasian Psychiatry. 2010;18:413.
  8. Deplin (Prescribing information). Covington, La.: Pamlab; 2011. http://www.deplin.com/. Accessed Aug. 27, 2012.
  9. Kung S (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 7, 2012.
  10. Understanding major depression. National Alliance on Mental Health. http://www.nami.org/Template.cfm?section=Search&Template=Search/SearchDisplay.cfm. Accessed June 20, 2012.
  11. Indications for electroconvulsive therapy (ECT) in unipolar depression and its efficacy. http://www.uptodate.com/index. Accessed June 20, 2012.
  12. Carpenter DJ. St. John's wort and S-adenosyl amethione as "natural" alternatives to conventional antidepressants in the era of the suicidality boxed warning: What is the evidence for clinically relevant benefit? Alternative Medicine Review. 2011;16:17.
  13. Lamers F, et al. Stability and transitions of depressive subtypes over a 2-year follow-up. Physiological Medicine. 2012. In press. Accessed June 19, 2012.
  14. Hourani LL, et al. Influence of spirituality on depression, posttraumatic stress disorder, and suicidality in active duty military personnel. Depression Research and Treatment. 2012;2012:1.
  15. Depression and complementary health practices: What the science says. National Center for Complementary and Alternative Medicine. Dec. 2011. http://nccam.nih.gov/health/providers/digest/depression-science.htm. Accessed May 10, 2012.
  16. Viibryd (prescribing information). St. Louis, Mo.: Forest Pharmaceuticals; 2011. http://www.viibryd.com/. Accessed June 20, 2012.
  17. SAMe. Natural Medicines Comprehensive Database. http://naturaldatabase.therapeuticresearch.com/nd/Search.aspx?cs=MAYO&s=ND&pt=100&id=786&ds=adverse&lang=0. Accessed Aug. 3, 2012.
  18. Papakotas GI, et al. Folates and s-adenosylmethionine for major depressive disorder. Canadian Journal of Psychiatry. 2012;57:406.
  19. Marchand WR. Mindfulness-based stress reduction, mindfulness-based cognitive therapy, and Zen meditation for depression. Journal of Psychiatric Practice. 2012;18:233.
  20. Tanyi RA, et al. The effects of psychoneuroimmunology (PNI) based lifestyle intervention in modifying the progression of depression in clinically depressed adults. International Journal of Psychiatry in Medicine. 2011;42:151.
  21. Wu J, et al. Acupuncture for depression: A review of clinical applications. The Canadian Journal of Psychiatry. 2012;57:397.
  22. Chi J, et al. Tai chi and reduction of depressive symptoms for older adults: A meta-analysis of randomized trials. Geriatrics & Gerontology International. 2012. In Print. http://www.ncbi.nlm.nih.gov/pubmed/22680972. Accessed Aug. 28, 2012.
  23. Chan MF, et al. The effectiveness of music listening in reducing depressive symptoms in adults: A systemic review. Complementary Therapies in Medicine. 2011;19:332.
  24. McCaffrey R, et al. Garden walking and art therapy for depression in older adults: A pilot study. Research in Gerontological Nursing. 2011;4:237.
DS01181 Sept. 20, 2012

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