Atypical hyperplasia of the breast

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Complications

By Mayo Clinic staff

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Increased risk of breast cancer
If you've been diagnosed with atypical hyperplasia, you have an increased risk of breast cancer in the future. Women with atypical hyperplasia have a risk of breast cancer that is about four times higher than that of women who don't have atypical hyperplasia.

Being diagnosed with atypical hyperplasia at a younger age may increase the risk of breast cancer even more. Women diagnosed with atypical hyperplasia before age 45 have a greater risk of developing invasive breast cancer during their lifetimes, compared with older women, especially those older than 55.

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References
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  2. Bombonati A, et al. The molecular pathology of breast cancer progression. Journal of Pathology. 2011;223:307.
  3. Hartmann LC, et al. Benign breast disease and the risk of breast cancer. The New England Journal of Medicine. 2005;353:229.
  4. London SJ, et al. A prospective study of benign breast disease and the risk of breast cancer. Journal of the American Medical Association. 1992;267:941.
  5. Degnim AC, et al. Stratification of breast cancer risk in women with atypia: A Mayo cohort study. Journal of Clinical Oncology. 2007;25:2671.
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  7. Breast cancer risk reduction. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Aug. 17, 2011.
  8. Breast cancer screening and diagnosis. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed Aug. 17, 2011.
  9. Pruthi S (expert opinion). Mayo Clinic, Rochester, Minn. Aug. 31, 2011.
  10. Goss PE, et al. Exemestane for breast-cancer prevention in postmenopausal women. The New England Journal of Medicine. 2011;25:2381.
DS01018 Oct. 1, 2011

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