Autonomic neuropathy

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Symptoms

By Mayo Clinic staff

Signs and symptoms of autonomic neuropathy vary, depending on which parts of your autonomic nervous system are affected. They may include:

  • Dizziness and fainting upon standing (orthostatic, or postural, hypotension), caused by a drop in blood pressure
  • Urinary problems, including difficulty starting urination, overflow incontinence and inability to empty your bladder completely, which can lead to urinary tract infections
  • Sexual difficulties, including erectile dysfunction or ejaculation problems in men, and vaginal dryness and difficulties with arousal and orgasm in women
  • Difficulty digesting food, due to abnormal digestive function and slow emptying of the stomach (gastroparesis), which can cause a feeling of fullness after eating little, loss of appetite, diarrhea, constipation, abdominal bloating, nausea, vomiting and heartburn
  • Sweating abnormalities, such as excessive or decreased sweating, which affects the ability to regulate body temperature
  • Sluggish pupil reaction, making it difficult to adjust from light to dark and causing problems with driving at night
  • Exercise intolerance, which may occur if your heart rate remains unchanged instead of appropriately increasing and decreasing in response to your activity level

When to see a doctor
Seek medical care promptly if you begin experiencing any of the signs and symptoms of autonomic neuropathy. If you have diabetes, a compromised immune system or another chronic medical condition, see your doctor regularly to be checked for nerve damage.

The American Diabetes Association (ADA) recommends that people with type 2 diabetes be screened every year for autonomic neuropathy starting as soon as they receive their diabetes diagnosis. For people with type 1 diabetes, the ADA advises annual screening beginning five years after being diagnosed with diabetes.

References
  1. Freeman R. Autonomic peripheral neuropathy. Neurologic Clinics. 2007;25:277.
  2. Stevens MJ. Diabetic autonomic neuropathy. http://www.uptodate.com/home/index.html. Accessed Jan. 29, 2010.
  3. Autonomic neuropathy. American Diabetes Association. http://www.diabetes.org/living-with-diabetes/complications/neuropathy/autonomic-neuropathy.html. Accessed Feb. 22, 2010.
  4. Masharani U, et al. Pancreatic hormones and diabetes mellitus. In: Gardner DG, et al. Greenspan's Basic and Clinical Endocrinology. 8th ed. New York, N.Y.: McGraw-Hill Medical; 2007. http://www.accessmedicine.com/content.aspx?aID=2633151. Accessed Feb. 22, 2010.
  5. Diabetic neuropathies: The nerve damage of diabetes. National Institute of Diabetes and Digestive and Kidney Diseases. http://diabetes.niddk.nih.gov/DM/pubs/neuropathies/. Accessed Feb. 21, 2010.
  6. Boulton AJM, et al. Diabetic neuropathies: A statement from the American Diabetes Association. Diabetes Care. 2005;28:956.
  7. Disorders of the autonomic nervous system. In: Fauci AS, et al. Harrison's Principles of Internal Medicine. 17th ed. New York, N.Y.: McGraw-Hill Medical; 2008. http://www.accessmedicine.com/content.aspx?aID=2906166. Accessed Feb. 22, 2010.
  8. Vink AI. Diabetic autonomic neuropathy. Diabetes Care. 2003;26:1553.
  9. Autonomic nervous system. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/sec16/ch208/ch208a.html. Accessed Feb. 22, 2010.
  10. Ma J, et al. Diabetic gastroparesis: Diagnosis and management. Drugs. 2009;69:971.
  11. Bethanechol (prescribing information). Minneapolis, Minn.: Upsher-Smith Laboratories, Inc.; 2005. http://www.upsher-smith.com/PDFs/bethanechol.pdf. Accessed Feb. 22, 2010.
  12. Robinul and Robinul Forte (prescribing information). Atlanta, Ga.: Sciele Pharma, Inc.; 2006. http://www.shionogipharma.com/PI/Robinul%20PI.pdf. Accessed Feb. 22, 2010.
  13. Bansal V, et al. Diabetic neuropathy. Post Graduate Medical Journal. 2006;82:95.
  14. Sandroni P (expert opinion). Mayo Clinic, Rochester, Minn. March 1, 2010.
  15. Detrol (prescribing information). New York, N.Y.: Pharmacia and Upjohn; 2009. http://www.pfizer.com/files/products/uspi_detrol_la.pdf. Accessed March 8, 2010.
  16. Ditrol (prescribing information). Raritan, N.J.: Ortho McNeil Pharmaceuticals; 2008. http://www.ortho-mcneilpharmaceutical.com/sites/default/files/shared/pi/Lg%20Ditropan%20PI.pdf#zoom=100. Accessed March 8, 2010.
DS00544 April 15, 2010

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