Basal cell carcinoma

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Complications

By Mayo Clinic staff

Basal cell carcinomas that are diagnosed and treated early usually cause no problems. But untreated cancers, especially aggressive morpheaform tumors, can invade and destroy nearby muscles, nerves and bone. One unusual type of basal cell carcinoma — basosquamous — is capable of spreading to other parts of your body.

Basal cell carcinomas are also difficult to eliminate completely. Even after successful treatment, they may recur, often in the same place. Having more than one tumor initially or a tumor on the trunk of your body makes recurrence more likely.

A history of basal cell carcinoma may also increase the chance of developing more serious types of skin cancer, such as squamous cell carcinoma and even malignant melanoma — probably because of long-term sun exposure. Researchers are debating whether having basal cell carcinoma leads to an increased risk of other kinds of cancer.

References
  1. Wood GS, et al. Nonmelanoma skin cancers: Basal cell and squamous cell carcinomas. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone; 2008. http://www.mdconsult.com/das/book/body/119479231-3/0/1709/83.html?tocnode=55017273&fromURL=83.html#4-u1.0-B978-0-443-06694-8..50078-6--cesec29_2759. Accessed Feb. 6, 2009.
  2. Basal cell carcinoma. American Academy of Dermatology. http://www.aad.org/public/publications/pamphlets/sun_basal.html. Accessed Feb. 6, 2009.
  3. Detailed guide: Skin cancer - basal and squamous cell. American Cancer Society. http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_is_skin_cancer_51.asp. Accessed Feb. 6, 2009.
  4. Urist MM, et al. Melanoma and cutaneous malignancies. In: Townsend CM, et al. Townsend: Sabiston Textbook of Surgery. 18th ed. Philadelphia, Pa.: W.B. Saunders; 2007.http://www.mdconsult.com/das/book/body/119479231-5/0/1565/1.html?tocnode=54736195&fromURL=1.html#4-u1.0-B978-1-4160-3675-3..X5001-1--TOP_1. Accessed Feb. 6, 2009.
  5. Burns J. Bartter's syndrome and basal cell carcinoma. In: Ferri FF. Ferri's Clinical Advisor 2009. St. Louis, Mo.: Mosby; 2008. http://www.mdconsult.com/das/book/body/119515236-9/801847095/1701/79.html#4-u1.0-B978-0-323-04134-8..50005-7--cesec92_1598. Accessed Feb. 9, 2009.
  6. Sunscreen. The Skin Cancer Foundation. http://www.skincancer.org/the-scfs-guide-to-sunscreens.html. Accessed Feb. 6, 2009.
  7. Basal cell carcinoma of the skin. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/treatment/skin/HealthProfessional/page5. Accessed Feb. 6, 2009.
  8. Ridky TW. Nonmelanoma skin cancer. Journal of the American Academy of Dermatology. 2007;57:484.
  9. Neoplasia. In: Kumar V, et al. Robbins and Cotran's Pathologic Basis of Disease. 7th ed. Philadelphia, Pa.: Saunders Elsevier; 2005. http://www.mdconsult.com/das/book/body/119515236-4/801835407/1249/66.html#4-u1.0-B0-7216-0187-1..50011-0--cesec92_600. Accessed Feb. 6, 2009.
  10. Arsenic toxicity exposure pathways. U.S. Department of Health and Human Services. http://www.atsdr.cdc.gov/csem/arsenic/exposure_pathways.html. Accessed Feb. 6, 2009.
  11. Common questions about diet and cancer. American Cancer Society. http://www.cancer.org/docroot/PED/content/PED_3_2X_Common_Questions_About_Diet_and_Cancer.asp?sitearea=PED. Accessed Feb. 6, 2009.
  12. Food Groups to Encourage. In: U.S. Department of Health and Human Services and U.S. Department of Agriculture. Dietary Guidelines for Americans. 6th Edition. Washington, D.C.: U.S. Government Printing Office; 2005. http://www.health.gov/DietaryGuidelines/dga2005/document/html/chapter5.htm. Accessed Feb 6, 2009.
  13. Premalignant and malignant nonmelanoma skin tumors. In: Habif TP. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 4th ed. New York, N.Y.: Mosby; 2004. http://www.mdconsult.com/das/book/body/119515236-5/0/1195/157.html?tocnode=51442435&fromURL=157.html#4-u1.0-B0-323-01319-8..50023-6_2588. Accessed Feb. 6, 2009.

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April 2, 2009

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