Behcet's disease


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Definition

By Mayo Clinic staff

Behcet's (beh-CHETS) disease, also called Behcet's syndrome, is a rare disorder that causes inflammation in blood vessels throughout your body. The inflammation of Behcet's disease leads to numerous symptoms that may initially seem unrelated. The signs and symptoms of Behcet's disease — which may include mouth sores, eye inflammation, skin rashes and lesions, and genital sores — vary from person to person and may come and go on their own.

The exact cause of Behcet's is unknown, but it may be an autoimmune disorder, which means the body's immune system mistakenly attacks some of its own healthy cells. Both genetic and environmental factors may be responsible for Behcet's disease.

Treatment aims to reduce the signs and symptoms of Behcet's disease and to prevent serious complications, such as blindness.

References
  1. Saadoun D, et al. Behcet's disease. Orphanet Journal of Rare Diseases. 2012;7:1.
  2. Questions and answers about Behcet's disease. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Behcets_Disease/default.asp. Accessed Nov. 15, 2012.
  3. Mendes D, et al. Behcet's disease — A contemporary review. Journal of Autoimmunity. 2009;32:178.
  4. Ambrose NL, et al. Differential diagnosis and management of Behcet syndrome. Nature Reviews Rheumatology. In press. Accessed Jan. 13, 2013.
  5. Okada AA, et al. Multicenter study of infliximab for refractory uveoretinitis in Behcet disease. Archives of Ophthalmology. 2012;130:592.
  6. Arida A, et al. Anti-TNF agents for Behcet's disease: Analysis of published data on 369 patients. Seminars in Arthritis and Rheumatism. 2011;41:61.
  7. Benitah NR, et al. The use of biologic agents in the treatment of ocular manifestations of Behcet's disease. Seminars in Ophthalmology. 2011;26:295.
DS00822 March 8, 2013

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