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By Mayo Clinic staffDoctors don't know what causes Behcet's disease. Many believe Behcet's disease is an autoimmune disorder in which your body's defense system — your immune system — turns on itself. Rather than attack foreign invaders, such as bacteria and viruses, your immune system attacks healthy cells in your body.
Behcet's disease is likely caused by a combination of genetic and environmental factors. Some researchers believe a virus or bacterium may trigger Behcet's disease in people who have a certain genetic background. Other possible triggers that could set off the immune system could include chemicals or heavy metals.
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