• image.alt
  • With Mayo Clinic psychiatrist

    Daniel K. Hall-Flavin, M.D.

    read biography

Free

E-Newsletters

Subscribe to receive the latest updates on health topics. About our newsletters

  • Housecall
  • Alzheimer's caregiving
  • Living with cancer

Question

Bipolar treatment: Are bipolar I and bipolar II treated differently?

Is treatment for bipolar I different from treatment for bipolar II?

Answer

from Daniel K. Hall-Flavin, M.D.

Bipolar treatment generally involves taking medications and going to mental health counseling (psychotherapy) — whether you have bipolar I or bipolar II. However, there are some differences.

The types and doses of medications you're prescribed for bipolar treatment are based on your particular symptoms. These medications include:

  • Mood stabilizers. Examples of mood stabilizers include lithium (Lithobid, others), valproic acid (Depakene), divalproex sodium (Depakote) and lamotrigine (Lamictal). With bipolar I, controlling mania with one of these medications is essential. Unmanaged manic episodes can lead to irrational thinking, inappropriate decisions, and dangerous or out-of-control behavior. A less severe type of mania (hypomania) occurs with bipolar II. Hypomania isn't as disruptive as full-blown mania — but it can still be a problem, so mood-stabilizing medication is generally part of bipolar II treatment as well.
  • Antidepressants. For either type of bipolar disorder, a mood stabilizer alone may be enough to control depression. But if it isn't, adding an antidepressant may also be necessary. Examples of antidepressants used for bipolar disorder include fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil) and bupropion (Wellbutrin). With bipolar I, an antidepressant can sometimes trigger a manic episode. For this reason, antidepressants are always prescribed in combination with a mood stabilizer. Treating depression is usually the predominant concern with bipolar II disorder.
  • Antipsychotics. If symptoms of depression or mania persist in spite of treatment with other medications, adding an antipsychotic medication such as olanzapine (Zyprexa), risperidone (Risperdal) or quetiapine (Seroquel) may help.

Other approaches used to treat bipolar disorder include:

  • Mental health counseling (psychotherapy). Counseling is generally considered an important part of treatment for both kinds of bipolar disorder. It's most often done one-on-one, but some types of bipolar disorder counseling are done in groups or include family members.
  • Lifestyle changes. This is an important part of managing either type of bipolar disorder. Examples include getting plenty of sleep, getting regular exercise, and overcoming drug or alcohol abuse.
  • Hospital treatment. This can include an inpatient hospital stay or participation in an outpatient treatment program. Because bipolar I is generally more severe than bipolar II, the need for urgent outpatient treatment or hospitalization is more common with bipolar I.

The best treatment for either type of bipolar disorder varies from person to person. You may need to try different medications or combinations of medications to determine what works best. You'll need to meet with your doctor on a regular basis to see how well your treatment is working, and make periodic adjustments to your medication to keep symptoms and side effects under control.

Next question
Bipolar disorder in children: Is it possible?
References
  1. Stovall J. Bipolar disorder: Treatment. http://www.uptodate.com/home/index.html. Accessed Nov. 13, 2009.
  2. Muzina DJ. Bipolar spectrum disorder: Differential diagnosis and treatment. Primary Care Clinics in Office Practice. 2007;34:521.
  3. Practice guideline for the treatment of patients with bipolar disorder. 2nd ed. American Psychiatric Association. Arlington, Va.: http://www.psychiatryonline.com/content.aspx?aID=50099. Accessed Nov 13, 2009.
  4. Frye MA (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 12, 2010.
AN02049 Feb. 5, 2010

© 1998-2012 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

Print Share Reprints

Advertisement


Text Size: smaller largerlarger