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By Mayo Clinic staffPrompt treatment with antibiotics usually resolves the infection. If treatment is delayed, however, the infection can quickly lead to joint degeneration — usually within five to seven days — and permanent damage. Complications of septic arthritis often include osteoarthritis and joint deformity. In severe cases, the joint may need to be surgically reconstructed. If the infection affects a prosthetic joint, the prosthetic joint may need to be replaced.