Risk factorsBy Mayo Clinic staff
It's not clear what causes bone cancer, but doctors have found certain factors are associated with an increased risk, including:
- Inherited genetic syndromes. Certain rare genetic syndromes passed through families increase the risk of bone cancer, including Li-Fraumeni syndrome and hereditary retinoblastoma.
- Paget's disease of bone. This precancerous condition that affects older adults increases the risk of bone cancer.
- Radiation therapy for cancer. Exposure to large doses of radiation, such as those given during radiation therapy for cancer, increases the risk of bone cancer in the future.
- Gebhardt MC, et al. Sarcomas of bone. In: Abeloff MD, et al. Abeloff's Clinical Oncology. 4th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2008:1945.
- Bone cancer. Fort Washington, Pa.: National Comprehensive Cancer Network. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp. Accessed June 29, 2011.
- Bone cancer: Questions and answers. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/Sites-Types/bone. Accessed June 29, 2011.