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By Mayo Clinic staffA number of factors can contribute to weakness in an artery wall and increase the risk of a brain aneurysm. These contributing factors include:
- Older age
- Smoking
- High blood pressure (hypertension)
- Hardening of the arteries (arteriosclerosis)
- Family history of brain aneurysm, particularly a first-degree relative, such as a parent or sibling
- Drug abuse, particularly the use of cocaine
- Head injury
- Heavy alcohol consumption
- Certain blood infections
- Lower estrogen levels after menopause
Some disorders present at birth are known to increase the risk of brain aneurysms. These include:
- Inherited connective tissue disorders, such as Ehlers-Danlos syndrome, that weaken blood vessels
- Polycystic kidney disease, an inherited disorder, that results in fluid-filled sacs in the kidneys and usually increases blood pressure
- Abnormally narrow aorta (coarctation of the aorta), the blood vessel that delivers oxygen-rich blood from the heart to the body
- Cerebral arteriovenous malformation (brain AVM), an abnormal connection between arteries and veins in the brain that interrupts the normal flow of blood between them
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- Rabinstein AA (expert opinion). Mayo Clinic, Rochester, Minn. May 11, 2009.