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Risk factors

By Mayo Clinic staff

A number of factors can contribute to weakness in an artery wall and increase the risk of a brain aneurysm. These contributing factors include:

  • Older age
  • Smoking
  • High blood pressure (hypertension)
  • Hardening of the arteries (arteriosclerosis)
  • Family history of brain aneurysm, particularly a first-degree relative, such as a parent or sibling
  • Drug abuse, particularly the use of cocaine
  • Head injury
  • Heavy alcohol consumption
  • Certain blood infections
  • Lower estrogen levels after menopause

Some disorders present at birth are known to increase the risk of brain aneurysms. These include:

  • Inherited connective tissue disorders, such as Ehlers-Danlos syndrome, that weaken blood vessels
  • Polycystic kidney disease, an inherited disorder, that results in fluid-filled sacs in the kidneys and usually increases blood pressure
  • Abnormally narrow aorta (coarctation of the aorta), the blood vessel that delivers oxygen-rich blood from the heart to the body
  • Cerebral arteriovenous malformation (brain AVM), an abnormal connection between arteries and veins in the brain that interrupts the normal flow of blood between them
References
  1. Cerebral aneurysm fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/cerebral_aneurysm/detail_cerebral_aneurysm.htm. Accessed April 12, 2009.
  2. Cerebral aneurysm. American Association of Neurological Surgeons. http://www.neurosurgerytoday.org/what/patient_e/cerebral.asp. Accessed April 12, 2009.
  3. Singer RJ, et al. Etiology, clinical manifestations, and diagnosis of aneurysmal subarachnoid hemorrhage. http://www.uptodate.com/home/index.html. Accessed April 12, 2009.
  4. Bendok BR, et al. Cerebral aneurysms and vascular malformations. In: Noseworthy JH, ed. Neurological Therapeutics: Principles and Practice. New York, N.Y.: Martin Dunitz; 2003.
  5. Singer RJ, et al. Unruptured intracranial aneurysms. http://www.uptodate.com/home/index.html. Accessed April 9, 2009.
  6. Singer RJ, et al. Screening for intracranial aneurysm. http://www.uptodate.com/home/index.html. Accessed April 9, 2009.
  7. Soni D. Treatment options for cerebral aneurysm. American Association of Neurological Surgery. http://www.neurosurgerytoday.org/what/patient_e/treatment.asp. Accessed April 12, 2009.
  8. Rabinstein AA (expert opinion). Mayo Clinic, Rochester, Minn. May 11, 2009.

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May 23, 2009

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