How you prepare
By Mayo Clinic staffThe first step in the BRCA gene testing process is to meet with a genetic counselor. As soon as you consider having any genetic test, meet with a genetic counselor to determine whether it's appropriate for you and to discuss the potential risks, limitations and benefits.
The genetic counselor takes a detailed family and medical history, assesses your risk of developing cancer, discusses risks and benefits of genetic testing, and outlines your options.
To prepare for your meeting with a genetic counselor:
- Gather information about your family's medical history, especially that of close relatives.
- Document your personal medical history, including collecting records from specialists or results of previous genetic testing, if available.
- Write down questions you have for the counselor.
- Consider having a friend or family member accompany you to help ask questions or take notes.
Whether or not to proceed with genetic testing after you meet with a genetic counselor is up to you.
If you decide to have a BRCA gene test done, prepare yourself for the emotional and social implications that learning your genetic status might have. Test results could also fail to provide you with clear-cut answers regarding your cancer risk, so you should be ready to face that possibility, too.
- Hamilton R. Genetics: Breast cancer as an exemplar. Nursing Clinics of North America. 2009;44:327.
- BRCA1 and BRCA2: Cancer risk and genetic testing. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA. Accessed Dec. 1, 2010.
- BRCA-1 and BRCA-2. Lab Tests Online. http://www.labtestsonline.org/understanding/analytes/brca/multiprint.html. Accessed Dec. 1, 2010.
- Isaacs C, et al. Genetic testing for breast and ovarian cancer. http://www.uptodate.com/home/index.html. Accessed Dec. 1, 2010.
- Pruthi S (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 9, 2010.
- Litton JK, et al. Perceptions of screening and risk reduction surgeries in patients tested for a BRCA deleterious mutation. Cancer. 2009;115:1598.
- Hall MJ, et al. BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer. Cancer. 2009;115:2222.
- Meyer LA, et al. Evaluating women with ovarian cancer for BRCA1 and BRCA2 mutations: Missed opportunities. Obstetrics & Gynecology. 2010;115:945.
- Pruthi S, et al. Identification and management of women with BRCA mutations or hereditary predisposition for breast and ovarian cancer. Mayo Clinic Proceedings. 2010;85:1111.
- American College of Obstetricians and Gynecologists, et al. ACOG practice bulletin No. 103: Hereditary breast and ovarian cancer syndrome. Obstetrics & Gynecology. 2009;113:957.
- Peshkin BN, et al. Genetic counseling and psychosocial issues in women with an inherited predisposition to breast and ovarian cancer. http://www.uptodate.com/home/index.html. Accessed Dec. 1, 2010.
- Isaacs C, et al. Options for women with a genetic predisposition to breast and ovarian cancer. http://www.uptodate.com/home/index.html. Accessed Dec. 1, 2010.
- Esserman L, et al. Lessons learned from genetic testing. JAMA. 2010;304:1011.
- Berek JS, et al. Prophylactic and risk-reducing bilateral salpingo-oophorectomy. Obstetrics & Gynecology. 2010;116:733.


Find Mayo Clinic on