RisksBy Mayo Clinic staff
There's really no medical risk associated with being tested for a BRCA gene mutation. Rather, risks are tied to the emotional, financial, medical and social implications of your test results.
If you test positive for a BRCA gene mutation, you may face:
- Feelings of anxiety, anger, sadness or depression
- Concerns over possible insurance discrimination
- Strained family relationships over learning of a familial genetic mutation
- Difficult decisions about preventive measures that have long-term consequences
- Feelings of "inevitability" that you'll get cancer
On the other hand, if you test negative for a BRCA mutation or your results aren't clear-cut, you may experience:
- Uncertainty and concern that your result may not be a true negative result
- "Survivor guilt" if your family has a known gene mutation that may affect your loved ones
- Hamilton R. Genetics: Breast cancer as an exemplar. Nursing Clinics of North America. 2009;44:327.
- BRCA1 and BRCA2: Cancer risk and genetic testing. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA. Accessed Dec. 1, 2010.
- BRCA-1 and BRCA-2. Lab Tests Online. http://www.labtestsonline.org/understanding/analytes/brca/multiprint.html. Accessed Dec. 1, 2010.
- Isaacs C, et al. Genetic testing for breast and ovarian cancer. http://www.uptodate.com/home/index.html. Accessed Dec. 1, 2010.
- Pruthi S (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 9, 2010.
- Litton JK, et al. Perceptions of screening and risk reduction surgeries in patients tested for a BRCA deleterious mutation. Cancer. 2009;115:1598.
- Hall MJ, et al. BRCA1 and BRCA2 mutations in women of different ethnicities undergoing testing for hereditary breast-ovarian cancer. Cancer. 2009;115:2222.
- Meyer LA, et al. Evaluating women with ovarian cancer for BRCA1 and BRCA2 mutations: Missed opportunities. Obstetrics & Gynecology. 2010;115:945.
- Pruthi S, et al. Identification and management of women with BRCA mutations or hereditary predisposition for breast and ovarian cancer. Mayo Clinic Proceedings. 2010;85:1111.
- American College of Obstetricians and Gynecologists, et al. ACOG practice bulletin No. 103: Hereditary breast and ovarian cancer syndrome. Obstetrics & Gynecology. 2009;113:957.
- Peshkin BN, et al. Genetic counseling and psychosocial issues in women with an inherited predisposition to breast and ovarian cancer. http://www.uptodate.com/home/index.html. Accessed Dec. 1, 2010.
- Isaacs C, et al. Options for women with a genetic predisposition to breast and ovarian cancer. http://www.uptodate.com/home/index.html. Accessed Dec. 1, 2010.
- Esserman L, et al. Lessons learned from genetic testing. JAMA. 2010;304:1011.
- Berek JS, et al. Prophylactic and risk-reducing bilateral salpingo-oophorectomy. Obstetrics & Gynecology. 2010;116:733.