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Causes
By Mayo Clinic staffThe exact cause of broken heart syndrome is unclear. It's thought that a surge of stress hormones, such as adrenaline, might temporarily damage the hearts of some people. How these hormones might hurt the heart or whether something else is responsible isn't completely clear. A temporary constriction of the large or small arteries of the heart may play a role.
Broken heart syndrome is often preceded by an intense physical or emotional event. Some potential triggers of broken heart syndrome are:
- News of an unexpected death of a loved one
- A frightening medical diagnosis
- Domestic abuse
- Losing a lot of money
- A surprise party
- Having to perform publicly
- Physical stressors, such as an asthma attack, infection, a car accident or major surgery
How is broken heart syndrome different from a heart attack?
Most heart attacks are caused by a complete or near complete blockage of a heart artery. This blockage is due to a blood clot forming at the site of narrowing from fatty buildup (atherosclerosis) in the wall of the artery. In broken heart syndrome, the heart arteries are not blocked, although blood flow in the arteries of the heart may be reduced.
- Nef HM, et al. Mechanisms of stress (Takotsubo) cardiomyopathy. Nature Reviews. 2010;7:187.
- Wynne J, et al. Cardiomyopathy and myocarditis. In: Fauci AS, et al. Harrison's Principles of Internal Medicine. 17th ed. New York, N.Y.: McGraw Hill Medical; 2008. http://www.accessmedicine.com/content.aspx?aID=2902533. Accessed Dec. 8, 2010.
- Brenner ZR, et al. Takotsubo cardiomyopathy. Heart and Lung. 2008;37:1.
- Derrick D. The "broken heart syndrome": Understanding Takotsubo cardiomyopathy. Critical Care Nurse. 2009;29:49.
- Grogan M (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 14, 2010.
- Martin EA, et al. Endothelial function and vascular response to mental stress are impaired in patients with apical ballooning syndrome. Journal of the American College of Cardiology. 2010;56:1840.
- Rosenow E (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 11, 2010.
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