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Causes
By Mayo Clinic staffBrucellosis affects many wild and domestic animals. Cattle, goats, sheep, pigs, dogs, camels, wild boar and reindeer are especially prone to the disease. A form of brucellosis also affects harbor seals, porpoises and certain whales.
At least six species or strains of bacteria cause brucellosis in animals, but not all produce illness in humans. The bacteria spread from animals to people in three main ways:
- Raw dairy products. Brucella bacteria in the milk of infected animals can spread to humans in unpasteurized milk, ice cream, butter and cheeses. The bacteria can also be transmitted in raw or undercooked meat from infected animals.
- Inhalation. Brucella bacteria spread easily in the air. Farmers, laboratory technicians and slaughterhouse workers can inhale the bacteria.
- Direct contact. Bacteria in the blood, semen or placenta of an infected animal can enter your bloodstream through a cut or other wound. Because normal contact with animals — touching, brushing or playing — doesn't cause infection, people rarely get brucellosis from their pets. Even so, people with weakened immune systems should avoid handling dogs known to have the disease.
Brucellosis normally doesn't spread from person to person, but in a few cases, women have passed the disease to their infants during birth or through their breast milk. Rarely, brucellosis may spread through sexual activity or through contaminated blood or bone marrow transfusions.
- Brucellosis. Centers for Disease Control and Prevention. http://www.cdc.gov/ncidod/dbmd/diseaseinfo/Brucellosis_g.htm. Accessed Nov. 16, 2008.
- Everett ED. Microbiology, epidemiology, and pathogenesis of Brucella. http://www.uptodate.com/home/index.html. Accessed Nov. 17, 2008.
- Everett ED. Clinical manifestations, diagnosis, and treatment of brucellosis in adults. http://www.uptodate.com/home/index.html. Accessed Nov. 17, 2008.
- Franco MP, et al. Human brucellosis. Lancet Infectious Diseases. 2007;7:775.
- Purwar S. Human brucellosis: A burden of a half-million cases per year. Southern Medical Journal. 2007;100:1074.
- Brucellosis. New York State Department of Health. http://www.health.state.ny.us/diseases/communicable/brucellosis/fact_sheet.htm. Accessed Nov. 16, 2008.
- Brucellosis. Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases: Division of Bacterial Diseases. http://www.cdc.gov/ncidod/dbmd/diseaseinfo/Brcellosis_t.htm. Accessed Nov. 16, 2008.
- Pappas G. Treatment of brucellosis: Regimens containing aminoglycosides are most effective but difficult to implement in practice. BMJ. 2008;336:678.
- Hashmi S, et al. Rare red rash. American Journal of Medicine. 2008;121:862.
- Skalsky K, et al. Treatment of human brucellosis: Systematic review and meta-analysis of randomised controlled trials. BMJ. In press. Accessed Nov. 16, 2008.
- Centers for Disease Control and Prevention. Laboratory-acquired brucellosis - Indiana and Minnesota, 2006. Morbidity and Mortality Weekly Report. 2008;57:39Hashmi S, et al. Rare red rash. American Journal of Medicine. 2008;121:862.
- Everett ED. Brucellosis in children. http://www.uptodate.com/home/index.html. Accessed Nov. 17, 2008.
- Donch DA, et al. Status report - fiscal year 2007, Cooperative State-Federal Brucellosis Eradication Program. USDA, Animal and Plant Health Inspection Service. http://www.aphis.usda.gov/animal_health/animal_diseases/brucellosis/downloads/yearly_rpt.pdf. Accessed Nov. 19, 2008.
- Vaccine use following brucellosis and pseudorabies eradication. Center for Veterinary Biologics. www.aphis.usda.gov/animal_health/vet_biologics/publications/USAHA_CVB_2007_Handouts.pdf. Accessed Nov. 19, 2008.
