Byetta: Can diabetes drug also help me lose weight?

Tell me about the diabetes drug Byetta. Can it really help people with diabetes lose weight? Is it only available to people with diabetes?

- No name / No state given

Mayo Clinic endocrinologist Maria Collazo-Clavell, M.D., and colleagues answer select questions from readers.

Answer

Although taken by injection, exenatide (Byetta) is not insulin. Byetta improves blood sugar control by mimicking the action of the hormone incretin. Among other things, Byetta allows insulin to work more effectively in the body.

Studies of Byetta found that it not only improved blood sugar control but also led to weight loss. It's unclear exactly how Byetta causes weight loss, but one effect of the drug is that it delays the movement of food from the stomach into the small intestine. As a result, people taking Byetta may feel "full" faster and longer, so they eat less. The most common side effect with Byetta is mild to moderate nausea, which improves with time in most people.

Byetta is designed for people who have diabetes and has not been studied as a weight-loss aid in people with normal blood sugar. If you have diabetes and wonder if Byetta may be helpful, talk to your doctor.