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Risk factors

By Mayo Clinic staff

Anyone can develop canker sores, but these factors make you more susceptible:

  • Being female. Canker sores, especially clusters of small lesions, are more common in women.
  • Having a family history. About one-third of people with recurrent canker sores have a family history of the disorder. This may be due to heredity or to a shared factor in the environment, such as certain foods or allergens.
Preparing for your appointment Causes
References
  1. Morelli JG. Disorders of the mucous membranes. In: Kliegman RM, et al. Nelson Textbook of Pediatrics. 18th ed. Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/174218004-3/925169573/1608/1550.html#4-u1.0-B978-1-4160-2450-7..50665-4--cesec7_12116. Accessed Dec. 4, 2009.
  2. Leggiadro RJ. Infections of the oral cavity. In: Long SS, et al., eds. Principles and Practice of Pediatric Infectious Diseases. 3rd ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2008. http://www.mdconsult.com/das/book/body/174218004-3/925169573/1679/31.html#4-u1.0-B978-0-443-06687-0..50030-8--cesec16_721. Accessed Dec. 4, 2009.
  3. Travers JB, et al. Physiology of the oral cavity. In: Cummings CW, et al. Otolaryngology: Head & Neck Surgery. 4th ed. http://www.mdconsult.com/das/book/body/174218004-4/0/1263/586.html?tocnode=49543605&fromURL=586.html#4-u1.0-B0-323-01985-4..50067-8--cesec61_2453. Accessed Dec. 4, 2009.
  4. Common mouth sores. American Dental Association. http://www.ada.org/public/topics/mouth_sores.asp. Accessed Dec. 4, 2009.
  5. Mouth sores. The Merck Manuals: Home Edition for Patients and Caregivers. http://www.merck.com/mmhe/sec08/ch112/ch112a.html. Accessed Dec. 4, 2009.
  6. Amsterdam JT. Oral medicine. In: Marx JA, et al., eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 6th ed. St. Louis, Mo.: Mosby; 2006. http://www.mdconsult.com/book/player/book.do?method=display&type=bookPage&decorator=header&eid=4-u1.0-B978-0-323-05472-0..00068-2--s0160&uniq=174218004&isbn=978-0-323-05472-0&sid=925188259.Accessed Dec. 4, 2009.
  7. Rakel D, et al. Recurrent aphthous ulceration. In: Rakel RE. Integrative Medicine. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/174218004-8/925191198/1494/118.html#4-u1.0-B978-1-4160-2954-0..50075-2_3684. Accessed Dec. 4, 2009.
  8. Gibson LE (expert opinion). Mayo Clinic, Rochester, Minn. Dec. 9, 2009.
  9. Benzocaine topical products: Sprays, gels and liquids — risk of methemoglobinemia. U.S. Food and Drug Administration. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm250264.htm. Accessed Apr. 8, 2011.
DS00354 April 14, 2011

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