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Complications
By Mayo Clinic staff
Unicentric Castleman disease
People with unicentric Castleman disease usually do well once the affected lymph node is removed, although having Castleman disease may increase your risk of lymphoma.
Multicentric Castleman disease
On the other hand, multicentric Castleman disease is much more serious and often life-threatening. Death from multicentric disease usually occurs due to a serious infection, failure of multiple organs, or cancer, such as lymphoma or Kaposi's sarcoma. The presence of HIV/AIDS tends to worsen the outcome.
References
- Aster JC, et al. Castleman's disease. http://www.uptodate.com/home/index.html. Accessed July 19, 2011.
- Castleman disease. American Cancer Society. http://www.cancer.org/acs/groups/cid/documents/webcontent/003093-pdf.pdf. Accessed July 19, 2011.
- About Castleman's disease. International Castleman's Disease Organization. http://www.castlemans.org/ICDO_booklet_v3.pdf. Accessed July 19, 2011.
- Pica F, et al. Transmission of human herpesvirus 8: An update. Current Opinion in Infectious Diseases. 2007;20:152.
- Bandera B, et al. Treatment of unicentric Castleman disease with neoadjuvant rituximab. Chest. 2010;138:1239.
- Reddy D, et al. HIV-associated multicentric Castleman disease. Current Opinion in Oncology. In press. Accessed [month day, 2011]. Accessed July 19, 2011.
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