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Complications
By Mayo Clinic staff
Unicentric Castleman disease
People with unicentric Castleman disease usually do well once the affected lymph node is removed, although having Castleman disease may increase your risk of lymphoma.
Multicentric Castleman disease
On the other hand, multicentric Castleman disease is much more serious and often life-threatening. Death from multicentric disease usually occurs due to a serious infection, failure of multiple organs, or cancer, such as lymphoma or Kaposi sarcoma. The presence of HIV tends to worsen the outcome.
- Castleman disease (Formerly Castleman's disease). American Cancer Society. http://documents.cancer.org/6636.00/6636.00.pdf. Accessed July 17, 2009.
- Aster JC, et al. Castleman's disease. http://www.uptodate.com/home/index.html. Accessed July 10, 2009.
- What is Castlemans disease. International Castleman's Disease Organization. http://www.castlemans.org/index.php?option=com_content&view=article&id=19&Itemid=27. Accessed July 17, 2009.
- Dham A, et al. Castleman disease. Current Opinion in Hematology. 2007;14:359.
- Pica F, et al. Transmission of human herpesvirus 8: An update. Current Opinion in Infectious Diseases. 2007;20:152.
- Dispenzieri A, et al. Treatment of Castleman's Disease, Current Treatment Options in Oncology. 2005;6:255.
