Tests and diagnosisBy Mayo Clinic staff
Tests and procedures used to diagnose celiac disease include:
- Blood tests. Elevated levels of certain substances in your blood (antibodies) indicate an immune reaction to gluten. These tests detect celiac disease even if you have only mild symptoms or none at all.
- Endoscopy. If your blood tests indicate celiac disease, your doctor may order an endoscopy to view your small intestine and to take a small tissue sample (biopsy) to analyze for damage to the villi.
- Capsule endoscopy. Capsule endoscopy uses a tiny wireless camera to take pictures of your entire small intestine. The camera sits inside a vitamin-sized capsule, which you swallow. As the capsule travels through your digestive tract, the camera takes thousands of pictures that are transmitted to a recorder.
It's important to be tested for celiac disease before trying a gluten-free diet. Eliminating gluten from your diet may change the results of blood tests so that they appear to be normal.
- Ludvigsson JF, et al. The Oslo definitions for coeliac disease and related terms. Gut. 2013;62:43.
- AskMayoExpert. What are the most common manifestations of celiac disease today? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2012.
- Celiac disease. National Digestive Diseases Information Clearinghouse. http://digestive.niddk.nih.gov/ddiseases/pubs/indigestion/index.aspx. Accessed March 20, 2013.
- Scanlon SA, et al. Update on celiac disease — etiology, differential diagnosis, drug targets, and management advances. Clinical and Experimental Gastroenterology. 2011;4:297.
- Rashtak S, et al. Review article: Coeliac disease, new approaches to therapy. Alimentary Pharmacology & Therapeutics. 2012;35:768.
- Rubio-Tapia A, et al. The prevalence of celiac disease in the United States. American Journal of Gastroenterology. 2012;107:1538.
- Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed March 21, 2013.
- Rubio-Tapia, A, et al. Prevalence of small intestine bacterial overgrowth diagnosed by quantitative culture of intestinal aspirate in celiac disease. Journal of Clinical Gastroenterology. 2009;43:157.
- Rubio-Tapia A, et al. Classification and management of refractory coeliac disease. Gut. 2010;59:547. Accessed March 29, 2013.
- Walker MM, et al. An update in the diagnosis of coeliac disease. Histopathology. 2011;59:166.
- Rubio-Tapia A, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology. 2009;137:88.
- Presutti, RJ. Celiac disease. American Family Physician. 2007;76:1795.