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Causes

By Mayo Clinic staff

Cerebral palsy is caused by an abnormality or disruption in brain development, usually before a child is born. In many cases, the exact trigger of this abnormality isn't known. Factors that may lead to problems with brain development include:

  • Random mutations in genes that control brain development
  • Maternal infections that affect the developing fetus
  • Fetal stroke, a disruption of blood supply to the developing brain
  • Lack of oxygen to the brain (asphyxia) related to difficult labor or delivery
  • Infant infections that cause inflammation in or around the brain
  • Traumatic head injury to an infant from a motor vehicle accident, fall or child abuse
Risk factors Symptoms
References
  1. Cerebral palsy: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/cerebral_palsy/detail_cerebral_palsy.htm. Accessed Sept. 27, 2010.
  2. Evaluating and diagnosing the child with cerebral palsy. American Academy of Neurology. http://www.aan.com/practice/guideline/index.cfm?fuseaction=home.view&guideline=124. Accessed Sept. 27, 2010.
  3. Cerebral palsy. American Academy of Pediatrics. http://www.healthychildren.org/English/health-issues/conditions/developmental-disabilities/Pages/Cerebral-Palsy.aspx. Accessed Sept. 28, 2010.
  4. Krigger KW. Cerebral palsy: An overview. American Family Physician. 2006;73:91.
  5. Ashwal S, et al. Practice parameter: Diagnostic assessment of the child with cerebral palsy: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2004;62:851.
  6. Cerebral palsy: Drug treatments for spasticity in children and adolescents. American Academy of Neurology. http://www.aan.com/practice/guideline/index.cfm?fuseaction=home.view&guideline=389. Accessed Sept. 27, 2010.
  7. Delgado MR, et al. Practice parameter: Pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology. 2010;74:336.
  8. Information for Healthcare Professionals: OnabotulinumtoxinA (marketed as Botox/Botox Cosmetic), abobotulinumtoxinA (marketed as Dysport) and rimabotulinumtoxinB (marketed as Myobloc). U.S. Food and Drug Administration. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm174949.htm. Accessed Sept. 30, 2010.
  9. Patterson MC (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 9, 2010.
DS00302 Nov. 13, 2010

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