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HPV infection: How does it cause cervical cancer?By Mayo Clinic staff
Original Article: http://www.mayoclinic.com/health/cervical-cancer/AN00386
- With Mayo Clinic gynecologist and obstetrician
Mary M. Gallenberg, M.D.read biographyclose window
Mary M. Gallenberg, M.D.Mary M. Gallenberg, M.D.
Dr. Mary Gallenberg is board certified by the American Board of Obstetrics and Gynecology and by the American Board of Internal Medicine in internal medicine and medical oncology.
An Antigo, Wis., native, Dr. Gallenberg is a consultant in the Department of Obstetrics & Gynecology at Mayo Clinic, Rochester, Minn., and an assistant professor at College of Medicine, Mayo Clinic.
Dr. Gallenberg has been with Mayo Clinic since 1990. She was on the Mayo Clinic Women's HealthSource editorial board and has been honored for excellence in teaching. She also won a Mayo Clinic Excellence Through Teamwork award.
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HPV infection: How does it cause cervical cancer?
How does HPV cause cervical cancer?
from Mary M. Gallenberg, M.D.
When a woman is exposed to genital human papillomavirus (HPV), her immune system usually prevents the virus from doing serious harm. But in a small number of women, the virus survives for years. Eventually, the virus can lead to the conversion of normal cells on the surface of the cervix into cancerous cells.
At first, cells may only show signs of a viral infection. Eventually, the cells may develop precancerous changes. This is known as cervical intraepithelial neoplasia, which usually goes away spontaneously. In some cases, however, cervical intraepithelial neoplasia may progress to invasive cervical cancer.
It's not clear why some women are more likely to develop cervical cancer. Some types of HPV are simply more aggressive than are others. Cigarette smoking also increases the risk of cervical cancer.
There are two HPV vaccines available — Gardasil and Cervarix. They offer protection from several of the most dangerous types of HPV. Gardasil is approved for boys and men, girls and women ages 9 to 26. Cervarix is approved for girls and women ages 9 to 25.
If you're sexually active, the best way to prevent HPV and other sexually transmitted infections is to remain in a mutually monogamous relationship with an uninfected partner. Otherwise, when you have sexual intercourse always have your partner use a condom. Regular screening for cervical cancer and precancerous changes of the cervix is important, too.Next question
Cervical dysplasia: Is it cancer?
- Palefsky JM, et al. Virology of human papillomavirus infections and the link to cancer. http://www.uptodate.com/home. Accessed Aug. 6, 2013.
- Holschneider CH. Cervical intraepithelial neoplasia: Definition, incidence, and pathogenesis. http://www.uptodate.com/home. Accessed Aug. 6, 2011.
- Cervical cancer prevention. National Cancer Institute. http://www.cancer.gov/cancertopics/pdq/prevention/cervical/Patient/page3. Accessed Aug. 6, 2013.
- Castle PE, et al. Recommendations for the use of human papillomavirus vaccines. http://www.uptodate.com/home. Accessed Aug. 6, 2013.
- Cervical cancer. American Cancer Society. http://www.cancer.org/cancer/cervicalcancer/detailedguide/cervical-cancer-risk-factors. Accessed Aug. 6, 2013.
- Gardasil (prescribing information). Whitehouse Station, N.J.: Merck & Co. Inc.; 2011. http://www.merck.com/product/usa/pi_circulars/g/gardasil/gardasil_pi.pdf. Accessed Aug. 6, 2013.
- Cervarix (prescribing information). Research Triangle Park, N.C.: GlaxoSmithKline; 2011. http://us.gsk.com/products/assets/us_cervarix.pdf. Accessed Aug. 6, 2013.
- Gay CL, et al. Prevention of sexually transmitted infections. http://www.uptodate.com/home. Accessed Aug. 6, 2013.