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Definition
By Mayo Clinic staffChildhood disintegrative disorder, also known as Heller's syndrome, is a condition in which children develop normally until ages 2 to 4, but then demonstrate a severe loss of social, communication and other skills.
Childhood disintegrative disorder is very much like autism. Both are among the group of disorders known as pervasive developmental disorders, or autism spectrum disorders. And both involve normal development followed by significant loss of language, social, play and motor skills. However, childhood disintegrative disorder typically occurs later than autism and involves a more dramatic loss of skills. In addition, childhood disintegrative disorder is far less common than autism.
Treatment for childhood disintegrative disorder involves a combination of medications, behavior therapy and other approaches.
- Childhood disintegrative disorder. In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed May 18, 2010.
- Pervasive developmental disorders. In: Hales RE, et al., eds. The American Psychiatric Publishing Textbook of Psychiatry. 5th ed. Arlington, Va.: American Psychiatric Association; 2008. http://www.psychiatryonline.com. Accessed May 18, 2010.
- Childhood disintegrative disorder. In: Kliegman RM, et al. Nelson Textbook of Pediatrics. 18th ed. Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/203193401-3/1005176842/1608/73.html#4-u1.0-B978-1-4160-2450-7..50031-1--cesec12_466 Accessed May 18, 2010.
- Pervasive developmental disorders. In: Stern TA, et al. Massachusetts General Hospital Comprehensive Clinical Psychiatry. St. Louis, Mo.: Mosby; 2008. http://www.mdconsult.com/das/book/body/203193401-5/1005177285/1657/637.html#4-u1.0-B978-0-323-04743-2..50071-8--cesec46_1911. Accessed May 18, 2010.
- Augustyn M. Terminology, epidemiology, and pathogenesis of autism spectrum disorders. http://www.uptodate.com/home/index.html. Accessed May 18, 2010.
- Autism spectrum disorders (pervasive developmental disorders). National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/autism/complete-index.shtml. Accessed May 18, 2010.
- Augustyn M. Diagnosis of autism spectrum disorders. http://www.uptodate.com/home/index.html. Accessed May 18, 2010.
- Hoecker JL (expert opinion). Mayo Clinic, Rochester, Minn. May 18, 2010.
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