Cholestasis of pregnancy

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Risk factors

By Mayo Clinic staff

Factors that increase the risk of developing cholestasis of pregnancy include:

  • A personal or family history of cholestasis of pregnancy
  • A history of liver damage
  • A twin pregnancy
  • A pregnancy achieved by in vitro fertilization

After you've had the condition once, the risk of developing it during a subsequent pregnancy may be as high as 70 percent.

Complications Causes
References
  1. Bacq Y, et al. Cholestasis of pregnancy. http://www.uptodate.com/home/index.html. Accessed Aug. 31, 2011.
  2. Geenes V, et al. Intrahepatic cholestasis of pregnancy. World Journal of Gastroenterology. 2009;15:2049.
  3. Liver disorders in pregnancy. March of Dimes. http://www.marchofdimes.com/professionals/14332_14543.asp. Accessed Sept. 1, 2011.
  4. Riely CA, et al. Intrahepatic cholestasis of pregnancy. Clinics in Liver Disease. 2004;8:167.
  5. Skin conditions during pregnancy. The American College of Obstetricians and Gynecologists. http://www.acog.org/publications/patient_education/bp169.cfm. Accessed Sept. 6, 2011.
  6. Cappell MS. Hepatic and gastrointestinal diseases. In: Gabbe SG, et al. Obstetrics: Normal and Problem Pregnancies. 5th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2007. http://www.mdconsult.com/books/linkTo?type=bookPage&isbn=978-0-443-06930-7&eid=4-u1.0-B978-0-443-06930-7..50045-1. Accessed Sept. 6, 2011.
  7. Burrows R, et al. Interventions for treating cholestasis in pregnancy. Cochrane Database of Systematic Reviews. 2009:CD000493. http://www2.cochrane.org/reviews. Accessed Sept. 6, 2011.
  8. SAMe. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Sept. 6, 2011.
  9. Pathak B, et al. Cholestasis of pregnancy. Obstetrics and Gynecology Clinics of North America. 2010;37:269.
  10. Harms RW (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 21, 2011.
DS01033 Oct. 12, 2011

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