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    Thomas Behrenbeck, M.D., Ph.D.

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Question

Cholesterol level: Can it be too low?

Can your total cholesterol level be too low?

Answer

from Thomas Behrenbeck, M.D., Ph.D.

A high blood cholesterol level increases your risk of coronary artery disease. Lower cholesterol is usually better, but in rare cases, having a low level of low-density lipoprotein (LDL, or "bad") cholesterol or a low total cholesterol level could increase your risk of some health problems. Doctors are still trying to find out more about the connection between low cholesterol and health risks.

Although the risks are rare, low levels of LDL cholesterol may increase your risk of:

  • Cancer
  • Depression
  • Anxiety
  • Preterm birth and low birth weight if your cholesterol is low while you're pregnant

Ideally, your total cholesterol and LDL cholesterol levels should fall in these ranges:

  • Total cholesterol below 200 milligrams per deciliter (mg/dL), or 5.2 millimoles per liter (mmol/L)
  • LDL cholesterol below 100 mg/dL (2.6 mmol/L) — or below 70 mg/dL (1.8 mmol/L) if you're at very high risk of heart disease

If you're concerned about your cholesterol level, consult your doctor. He or she can determine the cholesterol range most appropriate for you.

Next question
High cholesterol in children: How is it treated?
References
  1. Ahn J, et al. Prediagnostic total and high-density lipoprotein cholesterol and risk of cancer. Cancer Epidemiology, Biomarkers and Prevention. 2009;18;2814.
  2. Alsheikh-Ali AA, et al. Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer. Journal of the American College of Cardiology. 2007;50:409.
  3. Troisi A. Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk? Neuroscience and Biobehavioral Reviews. 2009;33:125.
  4. Papakostas GI, et al. Cholesterol in mood and anxiety disorders: Review of the literature and new hypotheses. European Neuropsychopharmacology. 2004;14:135.
  5. Edison RJ, et al. Adverse birth outcome among mothers with low serum cholesterol. Pediatrics. 2007;120:723.
  6. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3xsum.pdf. Accessed April 19, 2010.
AN01394 Aug. 12, 2010

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