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    Thomas Behrenbeck, M.D., Ph.D.

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Question

Cholesterol level: Can it be too low?

Can your total cholesterol level be too low?

Answer

from Thomas Behrenbeck, M.D., Ph.D.

A high blood cholesterol level increases your risk of coronary artery disease. Lower cholesterol is usually better, but in rare cases having a low level of low-density lipoprotein (LDL, or "bad") cholesterol or a low total cholesterol level could increase your risk of some health problems. Doctors are still trying to find out more about the connection between low cholesterol and health risks.

Although the risks are rare, low levels of LDL cholesterol may increase your risk of:

  • Cancer
  • Depression
  • Anxiety
  • Preterm birth and low birth weight if your cholesterol is low while you're pregnant

These conditions should be considered if your cholesterol suddenly drops significantly, without any other explanation, such as taking cholesterol medications, dieting or exercise. If you're concerned about your cholesterol level, consult your doctor. He or she can determine the cholesterol range most appropriate for you.

Next question
Cholesterol test kits: Are they accurate?
References
  1. Ahn J, et al. Prediagnostic total and high-density lipoprotein cholesterol and risk of cancer. Cancer Epidemiology, Biomarkers and Prevention. 2009;18:2814.
  2. Alsheikh-Ali AA, et al. Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer. Journal of the American College of Cardiology. 2007;50:409.
  3. Troisi A. Cholesterol in coronary heart disease and psychiatric disorders: Same or opposite effects on morbidity risk? Neuroscience and Biobehavioral Reviews. 2009;33:125.
  4. Boscarino JA, et al. Low serum cholesterol and external-cause mortality: Potential implications for research and surveillance. Journal of Psychiatric Research. 2009;43:848.
  5. Edison RJ, et al. Adverse birth outcome among mothers with low serum cholesterol. Pediatrics. 2007;120:723.
  6. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/guidelines/cholesterol/atp3xsum.pdf. Accessed Oct. 10, 2012.
AN01394 Dec. 14, 2012

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