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Definition
By Mayo Clinic staff
Cirrhosis (sih-ROW-sis) is scarring of the liver. Your liver is a large organ that is located in your upper abdomen. The liver carries out several essential functions, such as detoxifying harmful substances in your body, purifying your blood and manufacturing vital nutrients.
Cirrhosis occurs in response to chronic damage to your liver. With mild cirrhosis, your liver can repair itself and continue to do its job. But with more advanced cirrhosis, more and more scar tissue forms in the liver, making it impossible to function adequately.
A number of diseases and conditions can cause the chronic liver damage that leads to cirrhosis.
- Cirrhosis. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/cirrhosis/index.htm. Accessed Nov. 12, 2010.
- Ferri FF. Cirrhosis. In: Ferri FF. Ferri's Clinical Advisor 2011. Philadelphia, Pa.: Mosby; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-0-323-05610-6..C2009-0-38600-6--TOP&isbn=978-0-323-05610-6&about=true&uniqId=230100505-53. Accessed Nov. 12, 2010.
- Understanding cirrhosis of the liver. American Gastroenterological Association. http://www.gastro.org/frame-templates/print_template.cfm. Accessed Nov. 12, 2010.
- Jones AL, et al. Hepatic toxicology. In: Shannon MW, et al. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. 4th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/books/about.do?about=true&eid=4-u1.0-B978-0-7216-0693-4..50002-5&isbn=978-0-7216-0693-4&uniqId=226391226-4. Accessed Nov. 12, 2010.
- Your liver. Your life. American Liver Foundation. http://www.yourliver.org/Liver-Wellness-Presentation.pdf. Accessed Nov. 12, 2010.
- Sanchez W, et al. Liver cirrhosis. The American College of Gastroenterology. http://www.acg.gi.org/patients/gihealth/livercirrhosis.asp. Accessed Nov. 12, 2010.
- Rambaldi A, et al. S-adenosyl-L-methionine for alcoholic liver disease (review). Cochrane Database of Systematic Reviews. 2006:CD002235.
- Rambaldi A, et al. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases (review). Cochrane Database of Systematic Reviews. 2007:CD003620.
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