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Tests and diagnosis
By Mayo Clinic staffMost cases of cleft lip and cleft palate are discovered at birth, but they're increasingly being diagnosed by ultrasound before the baby is born. If fetal ultrasound shows a cleft, your doctor may offer amniocentesis — removal of a sample of amniotic fluid from your uterus — to check for chromosomal abnormalities, since cleft lip and palate can be part of a genetic syndrome.
After birth, genetic testing may help determine the best treatment for your child, especially if the cleft is associated with a genetic condition. Genetic testing also informs parents of their risk of having additional children with cleft lip or cleft palate.
- Cleft lip and cleft palate. March of Dimes. http://www.marchofdimes.com/printableArticles/14332_1210.asp. Accessed April 5, 2009.
- Moreau JL, et al. Tissue engineering solutions for cleft palates. Journal of Oral and Maxillofacial Surgery. 2007;65:2503.
- Cleft lip and palate repair. American Society of Plastic Surgeons. www1.plasticsurgery.org/ebusiness4/ProductCatalog/pdf/brochures/Cleft_Lip.pdf. Accessed April 5, 2010.
- Mossey PA, et al. Cleft lip and palate. The Lancet. 2009;374:1773.
- Hoffman WY. Cleft Lip & Palate. In: Lalwani AK. Current Diagnosis & Treatment in Otolaryngology — Head & Neck Surgery. 2nd ed. New York, N.Y.: McGraw-Hill; 2008. http://www.accessmedicine.com/content.aspx?aID=2826340&searchStr=cleft+lip#2826340. Accessed April 5, 2010.
- Craniofacial abnormalities. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/print/see19/ch288/ch288d.html. Accessed April 5, 2010.
- Burns JL. Plastic surgery (cleft lip and palate). In: Townsend CM Jr, et al. Sabiston Textbook of Surgery. 18th ed. Philadelphia, Pa.: Saunders Elsevier; 2008. http://www.mdconsult.com/das/book/body/1932697333/978681486/1565/708.html#4-u1.0-B978-1-4160-3675-3..50077-0--cesec9_4303. Accessed April 5, 2010.
- Wilkins-Haug L. Prenatal diagnosis of orofacial clefts. http://www.uptodate.com/home/index.html. Accessed April 5, 2010.
- Stothard KJ, et al. Maternal overweight and obesity and the risk of congenital anomalies: A systematic review and meta-analysis. JAMA. 2009;301:636.
- The school years: An introduction to psychology. Cleft Lip & Palate Association. http://www.clapa.com/news/article/901/. Accessed April 9, 2010.
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