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Risk factors
By Mayo Clinic staffSome research studies indicate that using certain medications may increase your risk of collagenous colitis and lymphocytic colitis. But not all studies agree. Medications linked to these conditions include:
- Clozapine (Clozaril)
- Entacapone (Comtan)
- Esomeprazole (Nexium)
- Flutamide
- Lansoprazole (Prevacid)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen (Advil, Motrin, others)
- Omeprazole (Prilosec)
- Ranitidine (Zantac)
- Sertraline (Zoloft)
- Simvastatin (Zocor)
- Ticlopidine (Ticlid)
It's not clear why some people who use these medications develop collagenous colitis or lymphocytic colitis, while others don't.
- Wald A. Other diseases of the colon and rectum. In: Feldman M, et al. Sleisinger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa.: Saunders; 2010. http://www.mdconsult.com/book/player/linkTo?type=bookHome&isbn=978-1-4160-6189-2&eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&uniq=200844987-3. Accessed Aug. 31, 2010.
- Collagenous colitis and lymphocytic colitis. National Institute for Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/collagenouscolitis/index.htm. Accessed Aug. 31, 2010.
- Dietrich CF. Lymphocytic and collagenous colitis (microscopic colitis). http://www.uptodate.com/home/index.html. Accessed Sept. 1, 2010.
- Tangri V, et al. Microscopic colitis: An update. Journal of Clinical Gastroenterology. 2009;43:293.
- Chande N, et al. Interventions for treating microscopic colitis: A Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders Review Group systematic review of randomized trials. American Journal of Gastroenterology. 2009;104:235.
- Nutrition therapy for diarrhea. Nutrition Care Manual. American Dietetic Association. http://nutritioncaremanual.org/index.cfm. Accessed Sept. 2, 2010.
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