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  • With Mayo Clinic gastroenterologist

    Michael F. Picco, M.D.

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Question

Splitting doses: A good strategy for colonoscopy preparation?

My doctor had me take bowel cleansing liquid the night before my colonoscopy and then the morning of. Is this a good colonoscopy preparation?

Answer

from Michael F. Picco, M.D.

Cleaning as much waste material as possible from your large intestine (colon) is crucial to a successful colonoscopy exam. Poor colonoscopy preparation can keep your doctor from finding polyps, tumors and other problems. It also increases the length of the exam and the risk of complications. In many cases, the exam has to be redone.

The biggest reason for poor colonoscopy preparation is people's distaste for having to drink large quantities of bowel cleaning solution. The most common colonoscopy preparation calls for drinking 1 gallon (4 liters) of a polyethylene glycol solution. Some studies have shown that more than a third of people don't complete the full preparation.

To make bowel preparation more tolerable, many doctors recommend splitting the dose of bowel preparation. Take 3 liters the night before the exam, and the remainder in the morning before the test. This regimen may not be possible if your colonoscopy is scheduled for early in the morning; you should consume the morning dose four to six hours prior to the procedure.

Studies have shown that the split-dose approach not only is more tolerable, but also does a better job of cleaning the colon. Better cleaning will lead to better results. One study found that doctors detected more common benign tumors (adenomas) in people who prepared with split doses than in people who prepared with single doses.

Ask your doctor about split-dose preparation for your next colonoscopy.

Next question
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References
  1. A-Rahim YI, et al. Bowel preparation for flexible sigmoidoscopy and colonoscopy. http://www.uptodate.com/index. Accessed Jan. 10, 2013.
  2. Kilgore TW, et al. Bowel preparation with split-dose polyethylene glycol before colonoscopy: A meta-analysis of randomized controlled trials. Gastrointestinal Endoscopy. 2011;73:1240.
  3. Enestvedt BK, et al. 4-Liter split-dose polyethylene glycol is superior to other bowel preparations, based on systematic review and meta-analysis. Clinical Gastroenterology and Hepatology. 2012;10:1225.
  4. Gurudu SR, et al. Increased adenoma detection rate with system-wide implementation of a split-dose preparation for colonoscopy. Gastrointestinal Endoscopy. 2012;76:603.
  5. Lee L, et al. Overview of colonoscopy in adults. http://www.uptodate.com/index. Accessed Jan. 14, 2013.
AN02198 Feb. 12, 2013

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