Definition
By Mayo Clinic staffComplex regional pain syndrome is an uncommon form of chronic pain that usually affects an arm or leg. Complex regional pain syndrome typically develops after an injury, surgery, stroke or heart attack, but the pain is out of proportion to the severity of the initial injury, if any.
The cause of complex regional pain syndrome isn't clearly understood. Treatment for complex regional pain syndrome is most effective when started early. In such cases, improvement and even remission are possible.
- Sheon RP. Etiology, clinical manifestations, and diagnosis of complex regional pain syndrome in adults. http://www.uptodate.com/home/index.html. Accessed Jan. 13, 2011.
- Sheon RP. Prevention and management of complex regional pain syndrome in adults. http://www.uptodate.com/home/index.html. Accessed Jan. 13, 2011.
- Complex regional pain syndrome fact sheet. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/reflex_sympathetic_dystrophy/detail_reflex_sympathetic_dystrophy.htm. Accessed Jan. 13, 2011.
- Neuropathic pain. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec16/ch209/ch209c.html#sec16-ch209-ch209c-285. Accessed Jan. 13, 2011.
- Shipton EA. Complex regional pain syndrome — Mechanisms, diagnosis, and management. Current Anaesthesia & Critical Care. 2009;20:209.


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