About our e-newsletters
- Free e-newsletters
- Mayo Clinic expertise
- We do not share your e-mail address
Housecall, our weekly general-interest e-newsletter, keeps you up to date on a wide variety of health topics with timely, reliable, practical information, recipes, blogs, questions and answers with Mayo Clinic experts and more. Our biweekly topic-specific e-newsletters also include blogs, questions and answers with Mayo Clinic experts, and other useful information that will help you manage your health.
Housecall Archives
Mayo Clinic Housecall
Stay up to date on the latest health information.
What you get
- Free weekly e-newsletter
- Mayo Clinic expertise
- Recipes, tools and other helpful information
- We do not share your e-mail address
Causes
By Mayo Clinic staff
Coronary artery disease is thought to begin with damage or injury to the inner layer of a coronary artery, sometimes as early as childhood. The damage may be caused by various factors, including:
- Smoking
- High blood pressure
- High cholesterol
- Diabetes
- Radiation therapy to the chest, as used for certain types of cancer
Once the inner wall of an artery is damaged, fatty deposits (plaques) made of cholesterol and other cellular waste products tend to accumulate at the site of injury in a process called atherosclerosis. If the surface of these plaques breaks or ruptures, blood cells called platelets will clump at the site to try to repair the artery. This clump can block the artery, leading to a heart attack.
- Coronary artery disease. National Lung, Heart, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/Cad/CAD_WhatIs.html. Accessed April 29, 2010.
- Morrow DA, et al. Chronic coronary artery disease. In: Libby P, et al., eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/book/player/book.do?method=display&type=bookPage&decorator=header&eid=4-u1.0-B978-1-4160-4106-1..50057-1&uniq=198193047&isbn=978-1-4160-4106-1&sid=989729689. Accessed April 29, 2010.
- Toth PP, et al. Coronary artery disease. In: Rakel RE. Rakel: Textbook of Family Medicine. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/198193047-17/0/1481/455.html#4-u1.0-B978-1-4160-2467-5..50041-5--cesec46_2228. Accessed April 29, 2010.
- Hall SL, et al. Secondary prevention of coronary artery disease. American Family Physician. 2010;81:289.
- Wilson PWF. Overview of the risk factors for cardiovascular disease. http://www.uptodate.com/home/index.html. Accessed April 29, 2010.
- Body composition tests. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=4489. Accessed April 29, 2010.
- Heart disease. National Center for Complementary and Alternative Medicine. http://nccam.nih.gov/health/heart-disease/. Accessed April 29, 2010.
- Grogan M (expert opinion). Mayo Clinic, Rochester, Minn. May 7, 2010.
- Lovett E, et al. Advising patients about herbs and nutraceuticals: Tips for primary care providers. Primary Care: Clinics in Office Practice. 2010;37:13.
Find Mayo Clinic on