Limited scleroderma (CREST syndrome)


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Definition

By Mayo Clinic staff

Limited scleroderma, or CREST syndrome, is one subtype of scleroderma — a condition that literally means "hardened skin."

The skin changes associated with limited scleroderma typically occur only in the lower arms and legs, and sometimes the face and throat. Limited scleroderma can also affect your digestive tract and can cause serious heart and lung disorders.

The problems caused by limited scleroderma may be minor. In some cases, however, the disease affects the lungs or heart, with potentially serious results. Limited scleroderma has no known cure, and treatments focus on managing symptoms and preventing serious complications.

Symptoms
References
  1. Habif TP. Scleroderma. In: Habif TP. Clinical Dermatology: A Color Guide to Diagnosis and Therapy. 5th ed. Edinburgh, U.K.; New York, N.Y.: Mosby Elsevier; 2010. http://www.mdconsult.com/books/page.do?sid=1149581384&eid=4-u1.0-B978-0-7234-3541-9..00026-2--s0540&isbn=978-0-7234-3541-9&type=bookPage§ionEid=4-u1.0-B978-0-7234-3541-9..00026-2--s0605&uniqId=239740754-5. Accessed April 23, 2011.
  2. Ferri FF. Scleroderma (progressive systemic sclerosis). In: Ferri FF. Ferri's Clinical Advisor 2011: Instant Diagnosis and Treatment. Philadelphia, Pa.: Mosby Elsevier; 2011. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-0-323-05610-6..00028-7--sc29005&isbn=978-0-323-05610-6&sid=1149581384&type=bookPage§ionEid=4-u1.0-B978-0-323-05610-6..00028-7--s29225&uniqId=239740754-5#4-u1.0-B978-0-323-05610-6..00028-7--s29225. Accessed April 23, 2011.
  3. Systemic sclerosis. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merckmanuals.com/professional/sec04/ch032/ch032h.html. Accessed April 23, 2011.
  4. Steen VD. The many faces of scleroderma. Rheumatic Disease Clinics of North America. 2008;34:1.
  5. Autoimmune connective tissue disease. In: Bope ET, et al. Conn's Current Therapy. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/books/page.do?eid=4-u1.0-B978-1-4377-0986-5..00007-7--sc0040&isbn=978-1-4377-0986-5&sid=1149586698&type=bookPage§ionEid=4-u1.0-B978-1-4377-0986-5..00007-7--s0715&uniqId=239740754-7#4-u1.0-B978-1-4377-0986-5..00007-7--s0715. Accessed April 23, 2011.
  6. Handout on health: Scleroderma. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Scleroderma/default.asp. Accessed April 23, 2011.
  7. Agarwal SK, et al. Genetics and genomic studies in scleroderma (systemic sclerosis). Rheumatic Disease Clinics of North America. 2008;34:17.
DS00580 June 2, 2011

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