Cytochrome P450 (CYP450) tests

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What you can expect

By Mayo Clinic staff

For cytochrome P450 tests, a sample of your DNA is taken for lab testing. It can be retrieved in one of two ways:

  • Blood test. Blood is drawn from a vein in your arm.
  • Cheek swab. A cotton swab is rubbed inside your cheek to get a skin cell sample.

After the procedure
Getting a cheek swab or having a blood sample drawn should take just a few minutes. Whichever type of test you have, your sample will be sent to a lab where your DNA is analyzed for specific genes.

Results How you prepare
References
  1. Mrazek DA. Psychiatric pharmacogenomic testing in clinical practice. Dialogues in Clinical Neuroscience. 2010;12:69.
  2. Wand L, et al. Genomics and drug response. The New England Journal of Medicine. 2011;364:1144.
  3. Goetz MP. Update on CYP2D6 and its impact on tamoxifen therapy. Clinical Advances in Hematology & Oncology. 2010;8:536.
  4. McAlpine DE, et al. Effect of cytochrome P450 enzyme polymorphisms on pharmacokinetics of venlafaxine. Therapeutic Drug Monitoring. 2011;33:14.
  5. Fleeman N, et al. Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: Systemic review and meta-analysis. The Pharmacogenomics Journal. 2011;11:1.
  6. Genetic testing — CYP450 genotyping to predict response to SSRIs used to treat non-psychotic depression in adults: EGAPP recommendation. Centers for Disease Control and Prevention. http://www.cdc.gov/genomics/gtesting/EGAPP/recommend/CYP450.htm. Accessed Aug. 29, 2012.
  7. Steimer W. Pharmacogenetics and psychoactive drug therapy: Ready for the patient? Therapeutic Drug Monitoring. 2010;32:381.
  8. Mrazek DA, et al. Facilitating clinical implementation of pharmacogenomics. JAMA. 2011:306:304.
  9. Kung S (expert opinion). Mayo Clinic Rochester, Minn. Aug. 15, 2012.
  10. Coumadin (prescribing information). Princeton, N.J.: Bristol-Myers Squibb Company; 2011. http://packageinserts.bms.com/pi/pi_coumadin.pdf. Accessed Aug. 21, 2012.
MY00135 Sept. 7, 2012

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