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By Mayo Clinic staffPeople most at risk of de Quervain's tenosynovitis tend to be those whose occupations or hobbies involve repetitive hand and wrist motions, such as carpenters, office workers and musicians. Even the awkward hand and wrist positions that new parents use in holding and rocking their children may cause the condition. De Quervain's tenosynovitis occurs most often in middle-aged women.